SCHEMBL8734665

SCHEMBL8734665

CC(=O)Oc1ccc2c(c1)CC(CNS(=O)(=O)c1cccc3ccccc13)C2

nearest known ligand 0.66

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 3/20 0.66
NPY5R Q15761 16/20 0.57
NPY1R P25929 9/20 0.57
ALDH1A1 P00352 1/20 0.45
ADRA2A P08913 1/20 0.45
MAPT P10636 1/20 0.45
HPGD P15428 1/20 0.45
AQP1 P29972 1/20 0.45
NPY2R P49146 1/20 0.45
NPY4R P50391 1/20 0.45
MCHR1 Q99705 1/20 0.45
TDP1 Q9NUW8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8734679 0.84 TBXA2R (0.67) TBXA2RNPY5RNPY1RALDH1A1
SCHEMBL8731672 0.84 TBXA2R (0.61) TBXA2RNPY5RNPY1RALDH1A1TDP1
SCHEMBL8734662 0.80 TBXA2R (0.83) TBXA2RNPY5RNPY1RALDH1A1ADRA2A
SCHEMBL8734692 0.78 KMT2A (0.52) TBXA2RALDH1A1MAPT
SCHEMBL8734707 0.78 TBXA2R (0.64) TBXA2RNPY5RALDH1A1MAPTHPGD
SCHEMBL8728399 0.78 TBXA2R (0.48) TBXA2RALDH1A1MAPTMCHR1
Water SCHEMBL2762310 0.76 TBXA2R (0.63) TBXA2RALDH1A1
SCHEMBL8734192 0.75 TBXA2R (0.49) TBXA2RNPY5RNPY1RALDH1A1MAPT
SCHEMBL8728445 0.74 TBXA2R (0.57) TBXA2RNPY5RNPY1RALDH1A1
SCHEMBL6039411 0.72 ACACB (0.69) TBXA2RNPY5RNPY1RALDH1A1ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5750524-A ADMINISTERING AN SULFAMIDE SUBSTITUTED INDAN DERIVATIVE ZERIA PHARMACEUTICAL CO., LTD. (JP) 1998-05-12 US disclosed