SCHEMBL8734735

SCHEMBL8734735

O=P(O)(O)COS(=O)(=O)c1c(Cl)cccc1Cl

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.46
GAA P10253 2/20 0.35
KMT2A Q03164 2/20 0.34
POLB P06746 1/20 0.34
ACP3 P15309 2/20 0.33
LMNA P02545 1/20 0.33
ITGAV P06756 1/20 0.33
CXCR2 P25025 1/20 0.33
ATM Q13315 1/20 0.33
DAGLA Q9Y4D2 1/20 0.32
MAPT P10636 1/20 0.32
PTK2B Q14289 1/20 0.32
CNR1 P21554 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8734975 0.89 SMN1; SMN2 (0.40) SMN1; SMN2KMT2ALMNAATM
SCHEMBL8763931 0.87 SMN1; SMN2 (0.40) SMN1; SMN2GAAKMT2APOLBLMNA
SCHEMBL27287291 0.87 PNMT (0.42) SMN1; SMN2LMNA
SCHEMBL8731811 0.85 SMN1; SMN2 (0.37) SMN1; SMN2KMT2AACP3
SCHEMBL8764723 0.84 SMN1; SMN2 (0.35) SMN1; SMN2GAAKMT2APOLBLMNA
SCHEMBL8762769 0.84 SMN1; SMN2 (0.38) SMN1; SMN2GAAKMT2APOLBLMNA
SCHEMBL8734622 0.83 SMN1; SMN2 (0.36) SMN1; SMN2LMNAMAPT
SCHEMBL8734598 0.82 SMN1; SMN2 (0.35) SMN1; SMN2
SCHEMBL8734841 0.81 SMN1; SMN2 (0.41) SMN1; SMN2GAAPOLBACP3LMNA
SCHEMBL27447647 0.80 SMN1; SMN2 (0.40) SMN1; SMN2POLBLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699390-B1 Compositions containing phosphosulfonate herbicides and dichloroacetamide safeners, and method of use ROHM & HAAS (US) 1998-10-07 EP claimed
EP-0511826-B1 Phosphosulfonate herbicides ROHM & HAAS (US) 1997-07-16 EP claimed
US-5500405-A Phosphosulfonate herbicides ROHM AND HAAS COMPANY (US) 1996-03-19 US claimed
EP-0699390-A2 Compositions containing phosphosulfonate herbicides and dichloroacetamide safeners, and method of use ROHM AND HAAS COMPANY (US) 1996-03-06 EP claimed
EP-0511826-A2 Phosphosulfonate herbicides ROHM AND HAAS COMPANY (US) 1992-11-04 EP claimed
EP-0699390-B1 Compositions containing phosphosulfonate herbicides and dichloroacetamide safeners, and method of use ROHM & HAAS (US) 1998-10-07 EP disclosed
EP-0699390-A2 Compositions containing phosphosulfonate herbicides and dichloroacetamide safeners, and method of use ROHM AND HAAS COMPANY (US) 1996-03-06 EP disclosed