SCHEMBL8735764

SCHEMBL8735764

COc1cc(S)ccc1Oc1cccc(N)c1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.53
CYP3A4 P08684 2/20 0.53
MAOB P27338 1/20 0.47
AR P10275 1/20 0.43
MAPT P10636 3/20 0.42
POLB P06746 1/20 0.42
HSP90AA1 P07900 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
TP53 P04637 1/20 0.41
TTR P02766 3/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
GAA P10253 2/20 0.38
KDM4E B2RXH2 1/20 0.38
CYP19A1 P11511 2/20 0.38
MAPK1 P28482 1/20 0.38
HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8732449 0.83 ALDH1A1 (0.55) ALDH1A1CYP3A4MAOBARMAPT
SCHEMBL632526 0.82 ALDH1A1 (0.62) ALDH1A1CYP3A4MAOBARMAPT
SCHEMBL5604780 0.80 ALDH1A1 (0.51) ALDH1A1CYP3A4MAOBARMAPT
SCHEMBL17781747 0.76 MAOB (0.67) ALDH1A1CYP3A4MAOBMAPTPOLB
SCHEMBL29929290 0.75 MAOB (0.72) ALDH1A1CYP3A4MAOBMAPTPOLB
SCHEMBL707810 0.75 MAOB (0.72) ALDH1A1CYP3A4MAOBMAPTPOLB
SCHEMBL12100718 0.75 L3MBTL1 (0.50) ALDH1A1CYP3A4ARMAPTSMN1; SMN2
SCHEMBL30222339 0.75 TTR (0.58) ALDH1A1CYP3A4MAOBMAPTSMN1; SMN2
SCHEMBL3811355 0.75 TTR (0.58) ALDH1A1CYP3A4MAOBMAPTSMN1; SMN2
SCHEMBL31180031 0.74 MAOB (0.59) ALDH1A1CYP3A4MAOBMAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0633294-B1 Polyimide based resin composition MITSUI CHEMICALS INC (JP) 1998-06-10 EP disclosed
US-5571875-A BLEND WITH FLUOROPOLYMER, GRAPHITE, POLYAMIDE AND LIQUID CRYSTAL POLYMER MITSUI TOATSU CHEMICALS, INC. (JP) 1996-11-05 US disclosed
EP-0430640-B1 Polyimide based resin composition MITSUI TOATSU CHEMICALS (JP) 1996-03-27 EP disclosed
EP-0643105-A1 Polyimide based resin composition MITSUI TOATSU CHEMICALS, Inc. (JP) 1995-03-15 EP disclosed
EP-0633294-A2 Polyimide based resin composition MITSUI TOATSU CHEMICALS, Inc. (JP) 1995-01-11 EP disclosed
EP-0488630-A2 Thermally stable polyimide and preparation process of polyimide MITSUI TOATSU CHEMICALS, Inc. (JP) 1992-06-03 EP disclosed
EP-0430640-A1 Polyimide based resin composition MITSUI TOATSU CHEMICALS, Inc. (JP) 1991-06-05 EP disclosed