SCHEMBL8735799

SCHEMBL8735799

CN1C(=O)c2c(Cl)cc(Cl)c(Cl)c2C1=O

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.36
ALDH1A1 P00352 2/20 0.35
HPGD P15428 2/20 0.34
KDM4E B2RXH2 1/20 0.34
AHR P35869 1/20 0.33
TSHR P16473 2/20 0.32
CASP1 P29466 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
PABPC1 P11940 1/20 0.32
KMT2A Q03164 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA7 P43166 1/20 0.31
CASP3 P42574 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1815113 0.76 UCHL1 (0.39) ALDH1A1TSHRCA1CA2CA7
SCHEMBL9485161 0.75 ALDH1A1 (0.40) CYP3A4ALDH1A1HPGDKDM4ECASP1
SCHEMBL17193053 0.74 MGAM (0.34) CYP3A4ALDH1A1HPGDKDM4ETSHR
SCHEMBL19009043 0.72 ALDH1A1 (0.44) ALDH1A1HPGDKDM4ECASP1HSD17B10
SCHEMBL8851653 0.71 DPP8 (0.53) ALDH1A1HPGDTSHRHSD17B10MEN1
SCHEMBL19009047 0.71 ALDH1A1 (0.43) ALDH1A1HPGDKDM4ECASP1HSD17B10
SCHEMBL9525319 0.67 ALDH1A1 (0.47) ALDH1A1HPGDKDM4EAHRHSD17B10
SCHEMBL5768752 0.67 CA12 (0.37) CYP3A4ALDH1A1HPGDKDM4EAHR
SCHEMBL4452692 0.66 CYP3A4 (0.64) CYP3A4ALDH1A1HPGDAHRTSHR
SCHEMBL20756369 0.65 MEN1 (0.48) CYP3A4ALDH1A1HPGDKDM4ETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0525066-B1 PREPARATION OF 3,4,6-TRIFLUOROPHTHALIC ACID OCCIDENTAL CHEM CO (US) 1997-06-18 EP claimed
US-5596104-A Preparation of 3,4,6-trifluorophthalic acid OCCIDENTAL CHEMICAL CORPORATION (US) 1997-01-21 US claimed
EP-0495426-A2 Preparation of 3,5-dichlorophthalic acid and 3,5-dichlorophthalic anhydride OCCIDENTAL CHEMICAL CORPORATION (US) 1992-07-22 EP claimed
US-5086188-A Preparation of 3,5-dichlorophthalic acid and 3,5-dichlorophthalic anhydride OCCIDENTAL CHEMICAL CORPORATION (US) 1992-02-04 US claimed
EP-0569620-B1 Method of making 2,4,5-trihalobenzoic acid OCCIDENTAL CHEM CO (US) 1998-06-24 EP disclosed
EP-0525066-B1 PREPARATION OF 3,4,6-TRIFLUOROPHTHALIC ACID OCCIDENTAL CHEM CO (US) 1997-06-18 EP disclosed
US-5596104-A Preparation of 3,4,6-trifluorophthalic acid OCCIDENTAL CHEMICAL CORPORATION (US) 1997-01-21 US disclosed
US-5336806-A Forming salt with hydroxide, precipitating, filtering, washing, dissolving, passing over activated carbon, and adding strong mineral acid OCCIDENTAL CHEMICAL CORPORATION (US) 1994-08-09 US disclosed
US-5264588-A Reaction of chlorophthalic acid with aniline OCCIDENTAL CHEMICAL CORPORATION (US) 1993-11-23 US disclosed
EP-0569620-A1 Method of making 2,4,5-trihalobenzoic acid OCCIDENTAL CHEMICAL CORPORATION (US) 1993-11-18 EP disclosed
US-5196590-A Heating a trihalophthalimide compound, water, mineral acid OCCIDENTAL CHEMICAL CORPORATION (US) 1993-03-23 US disclosed
EP-0525066-A4 PREPARATION OF 3,4,6-TRIFLUOROPHTHALIC ACID 1993-03-17 EP disclosed
EP-0525066-A1 PREPARATION OF 3,4,6-TRIFLUOROPHTHALIC ACID. OCCIDENTAL CHEM CO (US) 1993-02-03 EP disclosed
WO-1991016308-A1 PREPARATION OF 3,4,6-TRIFLUOROPHTHALIC ACID OCCIDENTAL CHEMICAL CORPORATION (US) 1991-10-31 WO disclosed