Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166319 | 0.91 | POLB (0.54) | POLBMAPTPTPN1ACACB | |
| SCHEMBL873835 | 0.85 | KMT2A (0.47) | POLBMAPTKMT2A | |
| SCHEMBL21591853 | 0.83 | ACACB (0.44) | POLBMAPTACACBKMT2A | |
| SCHEMBL874067 | 0.82 | HRH3 (0.50) | POLBKMT2A | |
| SCHEMBL873884 | 0.81 | ACACB (0.45) | ACACB | |
| SCHEMBL873481 | 0.78 | HRH3 (0.51) | — | |
| SCHEMBL874265 | 0.77 | TRPV1 (0.65) | KMT2A | |
| SCHEMBL874041 | 0.76 | MAPK1 (0.39) | KMT2A | |
| SCHEMBL873719 | 0.75 | POLB (0.50) | POLBACACBKMT2A | |
| SCHEMBL8606832 | 0.75 | POLB (0.56) | POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |