Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873481 | 0.91 | HRH3 (0.51) | LTA4HEPHX2HRH3 | |
| SCHEMBL5306939 | 0.78 | HDAC1 (0.57) | POLBACACBGAASMN1; SMN2LTA4H | |
| SCHEMBL23928240 | 0.77 | LTA4H (0.60) | POLBACACBGAASMN1; SMN2LTA4H | |
| SCHEMBL874067 | 0.77 | HRH3 (0.50) | POLBMAPK1SMN1; SMN2LTA4HHRH3 | |
| SCHEMBL4860911 | 0.76 | HRH3 (0.58) | MAPK1SMN1; SMN2EPHX2KDM4EALDH1A1 | |
| SCHEMBL11757768 | 0.75 | SMN1; SMN2 (0.62) | GAASMN1; SMN2KDM4EALDH1A1HRH3 | |
| SCHEMBL873835 | 0.75 | KMT2A (0.47) | POLBSMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL873597 | 0.75 | POLB (0.47) | POLBACACBKMT2A | |
| SCHEMBL873884 | 0.75 | ACACB (0.45) | ACACBGAALTA4HALDH1A1 | |
| SCHEMBL874244 | 0.75 | KMT2A (0.54) | MAPK1GAAKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055310-A1 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of The University of Michigan (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015054555-A1 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-04-16 | — | — | WO | disclosed |
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |