Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874067 | 0.89 | HRH3 (0.50) | LTA4HCYP2C19KCNH2 | |
| SCHEMBL873835 | 0.81 | KMT2A (0.47) | ALDH1A1 | |
| SCHEMBL873597 | 0.81 | POLB (0.47) | ACACB | |
| SCHEMBL874041 | 0.80 | MAPK1 (0.39) | CYP3A4ALDH1A1 | |
| SCHEMBL21591853 | 0.78 | ACACB (0.44) | ACACBALDH1A1 | |
| SCHEMBL873481 | 0.77 | HRH3 (0.51) | LTA4HHTT | |
| SCHEMBL15264078 | 0.76 | BIRC5 (0.54) | GAABIRC5ALDH1A1 | |
| SCHEMBL23291261 | 0.75 | CYP1A2 (0.56) | ACACBCYP1A2CYP2D6LTA4HCYP2C9 | |
| SCHEMBL873719 | 0.75 | POLB (0.50) | ACACBGAALTA4HALDH1A1 | |
| SCHEMBL11831932 | 0.74 | MCL1 (0.59) | GAAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |