Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873597 | 0.85 | POLB (0.47) | KMT2APOLBMAPT | |
| SCHEMBL874067 | 0.82 | HRH3 (0.50) | KMT2APOLBLMNASMN1; SMN2 | |
| SCHEMBL6166319 | 0.81 | POLB (0.54) | HPGDPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL873884 | 0.81 | ACACB (0.45) | ALDH1A1 | |
| SCHEMBL874041 | 0.78 | MAPK1 (0.39) | KMT2AMEN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8606832 | 0.78 | POLB (0.56) | POLBMAPTSMN1; SMN2 | |
| SCHEMBL873481 | 0.78 | HRH3 (0.51) | — | |
| SCHEMBL21591853 | 0.76 | ACACB (0.44) | KMT2AHPGDPOLBMAPTALDH1A1 | |
| SCHEMBL2263117 | 0.76 | L3MBTL1 (0.68) | KMT2AHPGDPOLBKDM4ELMNA | |
| SCHEMBL10428327 | 0.75 | TSHR (0.61) | KMT2AMEN1HPGDPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |