Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873719 | 0.91 | POLB (0.50) | HRH3LTA4HEPHX2 | |
| SCHEMBL874067 | 0.79 | HRH3 (0.50) | HRH3LTA4HACHE | |
| SCHEMBL873835 | 0.78 | KMT2A (0.47) | — | |
| SCHEMBL873597 | 0.78 | POLB (0.47) | — | |
| SCHEMBL15522527 | 0.78 | HRH3 (0.58) | HRH3LTA4HEPHX2PSMB1PSMB5 | |
| SCHEMBL873884 | 0.77 | ACACB (0.45) | LTA4HHTT | |
| SCHEMBL23928153 | 0.76 | LTA4H (0.64) | HRH3LTA4HEPHX2PSMB1PSMB5 | |
| SCHEMBL874041 | 0.75 | MAPK1 (0.39) | — | |
| SCHEMBL23928236 | 0.75 | LTA4H (0.63) | HRH3LTA4HEPHX2PSMB1PSMB5 | |
| SCHEMBL23928172 | 0.75 | LTA4H (0.63) | HRH3LTA4HEPHX2PSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |