Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.49 |
| ▸ | DPP4 | P27487 | 5/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.46 |
| ▸ | FAP | Q12884 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NTSR2 | O95665 | 2/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845158 | 0.85 | F2 (0.49) | DPP8DPP4DPP7ACEKCNH2 | |
| SCHEMBL9488598 | 0.80 | DPP8 (0.51) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL873575 | 0.79 | F2 (0.45) | DPP8DPP4DPP7ACECYP2C9 | |
| SCHEMBL9490722 | 0.79 | DPP8 (0.54) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL844890 | 0.75 | KCNH2 (0.51) | KCNH2CYP2C9CYP2C19HTTALDH1A1 | |
| SCHEMBL10119517 | 0.74 | ALDH1A1 (0.51) | CYP2C9CYP2C19HTTALDH1A1MAPK1 | |
| SCHEMBL845519 | 0.74 | ALDH1A1 (0.46) | CYP2C9CYP2C19F2HTTALDH1A1 | |
| SCHEMBL9614454 | 0.72 | KDM4E (0.53) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL29385022 | 0.72 | KDM4E (0.53) | DPP8DPP4DPP7DPP9FAP | |
| SCHEMBL9489209 | 0.71 | ALDH1A1 (0.48) | DPP8DPP4DPP7DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |