Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 8/20 | 0.40 |
| ▸ | GABRD | O14764 | 8/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 8/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 8/20 | 0.40 |
| ▸ | GABRE | P78334 | 8/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 8/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 8/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 8/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874527 | 0.80 | ALDH1A1 (0.57) | MAPTTP53CYP3A4MAPK1KMT2A | |
| SCHEMBL8536349 | 0.79 | HSD17B10 (0.50) | PIM1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11408384 | 0.79 | HSD17B10 (0.47) | PIM1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30621457 | 0.79 | MAOA (0.48) | MAPTTP53CYP3A4MAPK1KMT2A | |
| SCHEMBL874898 | 0.78 | PIM1 (0.32) | PIM1 | |
| SCHEMBL28798897 | 0.75 | PIM1 (0.54) | PIM1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL876845 | 0.72 | PIM1 (0.42) | PIM1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29416622 | 0.72 | PIM1 (0.58) | PIM1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2588529 | 0.72 | PIM1 (0.58) | PIM1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10323706 | 0.72 | PIM1 (0.47) | PIM1GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157448-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | GENENTECH, INC. | 2012-06-21 | — | — | US | disclosed |
| WO-2012071458-A1 | HETEROCYCLIC INHIBITORS OF BETA - SECRETASE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2012-05-31 | — | — | WO | disclosed |
| US-20120083501-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. | 2012-04-05 | — | — | US | disclosed |
| WO-2012040641-A2 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2012-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157448-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | BACE1, PSEN1, PSEN2 | PIM1 4091/4885GABRP 820/4885GABRD 1659/4885 |
| US-20120083501-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | BACE1, PSEN1, PSEN2 | PIM1 4091/4885GABRP 820/4885GABRD 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.