SCHEMBL8736890

SCHEMBL8736890

Cc1ccc(Sc2ccccc2)nc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.55
CYP11B2 P19099 1/20 0.55
SMN1; SMN2 Q16637 2/20 0.50
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
HPGD P15428 1/20 0.47
HTT P42858 1/20 0.47
HAO1 Q9UJM8 1/20 0.42
CCR1 P32246 1/20 0.41
CCR5 P51681 1/20 0.41
CCR8 P51685 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
LMNA P02545 1/20 0.41
MAPT P10636 1/20 0.41
NOTUM Q6P988 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.39
NOS3 P29474 1/20 0.39
NOS2 P35228 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8737320 0.82 SMN1; SMN2 (0.45) CYP11B1CYP11B2SMN1; SMN2NPC1RAB9A
SCHEMBL8737436 0.82 L3MBTL1 (0.50) CYP11B1CYP11B2SMN1; SMN2NPC1RAB9A
SCHEMBL8736568 0.81 NPC1 (0.44) CYP11B1CYP11B2SMN1; SMN2NPC1RAB9A
SCHEMBL3388888 0.81 CYP3A4 (0.46) CYP11B1CYP11B2SMN1; SMN2NPC1RAB9A
SCHEMBL8737245 0.80 HAO1 (0.51) CYP11B1CYP11B2SMN1; SMN2NPC1RAB9A
SCHEMBL10834017 0.79 HPGD (0.50) CYP11B1CYP11B2SMN1; SMN2NPC1RAB9A
SCHEMBL25218268 0.79 ALDH1A1 (0.50) CYP11B1CYP11B2SMN1; SMN2NPC1RAB9A
SCHEMBL30474703 0.79 ALDH1A1 (0.50) CYP11B1CYP11B2SMN1; SMN2NPC1RAB9A
SCHEMBL8736781 0.78 HAO1 (0.53) SMN1; SMN2NPC1RAB9AHPGDHAO1
SCHEMBL3378744 0.78 L3MBTL1 (0.53) CYP11B1CYP11B2SMN1; SMN2HPGDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150232455-A1 ANTI-VIRAL COMPOUNDS ABBVIE INC. 2015-08-20 US disclosed
US-20150203442-A1 Anthraquinone Analogs and Methods of Making and Using Thereof GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 2015-07-23 US disclosed
US-20120149706-A1 INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS DUMAS JACQUES (US) 2012-06-14 US disclosed
US-20120149706-A1 INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS DUMAS JACQUES (US) 2012-06-14 US disclosed
US-20120129893-A1 Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas DUMAS JACQUES (US) 2012-05-24 US disclosed
US-20120129893-A1 Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas DUMAS JACQUES (US) 2012-05-24 US disclosed
US-20120046290-A1 INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS BAYER HEALTHCARE LLC 2012-02-23 US disclosed
US-20120046290-A1 INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS BAYER HEALTHCARE LLC 2012-02-23 US disclosed
US-20120040977-A1 INHIBITORS OF HCV NS5A PRESIDIO PHARMACEUTICALS, INC. (US) 2012-02-16 US disclosed
US-20070244120-A1 INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS BAYER HEALTHCARE LLC 2007-10-18 US disclosed
US-20070244120-A1 INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS BAYER HEALTHCARE LLC 2007-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150203442-A1 Anthraquinone Analogs and Methods of Making and Using Thereof PCNA, KRAS, RECQL CYP11B1 939/4885CYP11B2 1137/4885SMN1; SMN2 3993/4885
US-20120149706-A1 INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS MAPK1, MAP3K1, MAP3K7 CYP11B1 1501/4885CYP11B2 1782/4885SMN1; SMN2 3445/4885
US-20120040977-A1 INHIBITORS OF HCV NS5A HAVCR2, MAVS, EIF2AK2 CYP11B1 3519/4885CYP11B2 3975/4885SMN1; SMN2 4634/4885
US-20120046290-A1 INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS MAPK1, MAP3K1, MAP3K7 CYP11B1 1501/4885CYP11B2 1782/4885SMN1; SMN2 3445/4885
US-20150232455-A1 ANTI-VIRAL COMPOUNDS HAVCR2, EIF2AK2, MAVS CYP11B1 2776/4885CYP11B2 3084/4885SMN1; SMN2 3721/4885
US-20070244120-A1 INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS BRAF, RAF1, ARAF CYP11B1 4144/4885CYP11B2 4342/4885SMN1; SMN2 4560/4885
US-20120129893-A1 Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas BRAF, RAF1, ARAF CYP11B1 4144/4885CYP11B2 4342/4885SMN1; SMN2 4560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.