Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28456854 | 0.84 | L3MBTL1 (0.42) | L3MBTL1ALDH1A1KDM4ELMNAHAO1 | |
| SCHEMBL11139134 | 0.83 | KMT2A (0.49) | L3MBTL1HTTHPGDCYP11B1CYP11B2 | |
| SCHEMBL10834017 | 0.81 | HPGD (0.50) | L3MBTL1HTTHPGDCYP11B1CYP11B2 | |
| SCHEMBL20379720 | 0.80 | MAPT (0.51) | L3MBTL1HPGDALDH1A1KDM4ECYP1A2 | |
| SCHEMBL510066 | 0.78 | HTT (0.47) | L3MBTL1HTTHPGDCYP11B1CYP11B2 | |
| SCHEMBL8866408 | 0.78 | HPGD (0.47) | L3MBTL1HTTHPGDCYP11B1CYP11B2 | |
| SCHEMBL8736890 | 0.78 | CYP11B1 (0.55) | L3MBTL1HTTHPGDCYP11B1CYP11B2 | |
| SCHEMBL31013394 | 0.78 | HTT (0.47) | L3MBTL1HTTHPGDCYP11B1CYP11B2 | |
| SCHEMBL11369506 | 0.78 | HPGD (0.52) | L3MBTL1HTTHPGDCYP11B1CYP11B2 | |
| SCHEMBL10483934 | 0.77 | CYP11B1 (0.55) | L3MBTL1HTTHPGDCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476428-B1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT6 RECEPTOR LIGANDS | PHARMACIA & UPJOHN CO LLC (US) | 2010-11-17 | — | — | EP | disclosed |
| US-6855709-B2 | Pyridyl sulfone derivatives | PHARMACIA & UPJOHN COMPANY (US) | 2005-02-15 | — | — | US | disclosed |
| EP-1476428-A1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT6 RECEPTOR LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-17 | — | — | EP | disclosed |
| US-20030186968-A1 | Pyridyl sulfone derivatives | PHARMACIA & UPJOHN COMPANY | 2003-10-02 | — | — | US | disclosed |
| WO-2003072548-A1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186968-A1 | Pyridyl sulfone derivatives | HTR6, TPH1, HTR1A | L3MBTL1 3129/4885HTT 1000/4885HPGD 715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.