Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | MMP1 | P03956 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22724758 | 0.90 | HPGD (0.58) | HPGDNPSR1MMP1MAPK14LMNA | |
| SCHEMBL15087749 | 0.89 | HPGD (0.59) | HPGDNPSR1MMP1MAPK14LMNA | |
| SCHEMBL255251 | 0.85 | GAA (0.76) | HPGDNPSR1LMNAALDH1A1MAPT | |
| SCHEMBL24124974 | 0.84 | HPGD (0.54) | HPGDNPSR1ALDH1A1KMT2AGAA | |
| SCHEMBL22724725 | 0.84 | HPGD (0.54) | HPGDNPSR1ALDH1A1KMT2AGAA | |
| SCHEMBL24124678 | 0.83 | HPGD (0.64) | HPGDNPSR1MAPTKMT2AGAA | |
| SCHEMBL17865783 | 0.83 | MLYCD (0.73) | HPGDNPSR1MAPK14LMNAALDH1A1 | |
| SCHEMBL19113064 | 0.82 | HPGD (0.55) | HPGDNPSR1MMP1MAPK14LMNA | |
| SCHEMBL13754242 | 0.82 | HPGD (0.66) | HPGDMMP1MAPK14LMNAALDH1A1 | |
| SCHEMBL24225548 | 0.82 | HPGD (0.71) | HPGDNPSR1ALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |