Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 14/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 14/20 | 0.70 |
| ▸ | MAPT | P10636 | 12/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.70 |
| ▸ | GAA | P10253 | 8/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | PDE5A | O76074 | 1/20 | 0.65 |
| ▸ | PDE1A | P54750 | 1/20 | 0.65 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.65 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.65 |
| ▸ | CFTR | P13569 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | ALB | P02768 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6114192 | 0.90 | MEN1 (0.73) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL6114077 | 0.90 | MEN1 (0.73) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL8738343 | 0.90 | MEN1 (0.73) | MEN1KMT2AMAPTALDH1A1GAA | |
| Bromide SCHEMBL6114277 | 0.89 | MEN1 (0.71) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL8737940 | 0.88 | MMP9 (0.72) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL8738033 | 0.87 | MEN1 (0.63) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL8739499 | 0.84 | MEN1 (0.82) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL8737946 | 0.84 | MEN1 (0.82) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL8738403 | 0.83 | MEN1 (0.70) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL8737941 | 0.82 | MEN1 (0.71) | MEN1KMT2AMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068209-A2 | BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-24 | — | — | WO | disclosed |
| US-20120129842-A1 | BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-05-24 | — | — | US | disclosed |
| US-20120129842-A1 | BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129842-A1 | BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | MMP1, MMP9, MMP2 | MEN1 2298/4885KMT2A 2435/4885MAPT 3531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.