Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | PTGIR | P43119 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31345518 | 1.00 | MAPT (0.58) | MAPTALDH1A1HPGDGAAALOX15 | |
| Nitrogen SCHEMBL10783880 | 0.97 | MAPT (0.55) | MAPTALDH1A1HPGDGAAALOX15 | |
| SCHEMBL31345533 | 0.86 | MAPT (0.61) | MAPTALDH1A1HPGDGAAALOX15 | |
| SCHEMBL8736422 | 0.84 | ACHE (0.48) | MAPTALDH1A1HPGDGAAALOX15 | |
| SCHEMBL2887157 | 0.84 | PTGIR (0.50) | MAPTALDH1A1MAPK1L3MBTL1PTGIR | |
| SCHEMBL9487582 | 0.83 | CA12 (0.60) | MAPTALDH1A1MAPK1PTGIRLRRK2 | |
| SCHEMBL38663217 | 0.83 | CA12 (0.60) | MAPTALDH1A1MAPK1PTGIRLRRK2 | |
| SCHEMBL31345532 | 0.81 | ALDH1A1 (0.56) | MAPTALDH1A1HPGDGAAALOX15 | |
| SCHEMBL31345528 | 0.81 | ALDH1A1 (0.56) | MAPTALDH1A1HPGDGAAALOX15 | |
| SCHEMBL31345529 | 0.81 | ALDH1A1 (0.56) | MAPTALDH1A1HPGDGAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149706-A1 | INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | DUMAS JACQUES (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120129893-A1 | Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas | DUMAS JACQUES (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120046290-A1 | INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER HEALTHCARE LLC | 2012-02-23 | — | — | US | disclosed |
| US-20070244120-A1 | INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER HEALTHCARE LLC | 2007-10-18 | — | — | US | disclosed |
| US-20070244120-A1 | INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER HEALTHCARE LLC | 2007-10-18 | — | — | US | disclosed |
| EP-0561847-B1 | PHOTOSENSITIVE POLYMERS AND PRINTING PLATES | LASTRA SPA (IT) | 1997-08-27 | — | — | EP | disclosed |
| EP-0561847-A1 | PHOTOSENSITIVE POLYMERS AND PRINTING PLATES. | LASTRA SPA (IT) | 1993-09-29 | — | — | EP | disclosed |
| WO-1992010523-A1 | PHOTOSENSITIVE POLYMERS AND PRINTING PLATES | LASTRA S.P.A. (IT) | 1992-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149706-A1 | INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | MAPK1, MAP3K1, MAP3K7 | MAPT 825/4885ALDH1A1 1451/4885HPGD 524/4885 |
| US-20120046290-A1 | INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | MAPK1, MAP3K1, MAP3K7 | MAPT 825/4885ALDH1A1 1451/4885HPGD 524/4885 |
| US-20070244120-A1 | INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS | BRAF, RAF1, ARAF | MAPT 3056/4885ALDH1A1 2759/4885HPGD 2117/4885 |
| US-20120129893-A1 | Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas | BRAF, RAF1, ARAF | MAPT 3056/4885ALDH1A1 2759/4885HPGD 2117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.