Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | CCR1 | P32246 | 3/20 | 0.53 |
| ▸ | CCR8 | P51685 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7731817 | 0.98 | LMNA (0.54) | LMNACCR1CCR8CYP3A4MAPT | |
| SCHEMBL8571632 | 0.79 | MAPT (0.57) | LMNACCR1CCR8CYP3A4MAPT | |
| SCHEMBL18704724 | 0.79 | LMNA (0.58) | LMNACCR1CCR8CYP3A4MAPT | |
| SCHEMBL30286995 | 0.77 | CCR1 (0.62) | LMNACCR1CCR8CYP3A4MAPT | |
| SCHEMBL874271 | 0.77 | LMNA (0.67) | LMNACCR1CCR8CYP3A4MAPT | |
| SCHEMBL529761 | 0.77 | CCR1 (0.62) | LMNACCR1CCR8CYP3A4MAPT | |
| SCHEMBL15706275 | 0.77 | L3MBTL1 (0.53) | CCR1CCR8MAPTKDM4EALDH1A1 | |
| Water SCHEMBL27996227 | 0.76 | CCR1 (0.61) | LMNACCR1CCR8CYP3A4MAPT | |
| O-Xylene SCHEMBL1420180 | 0.75 | LMNA (0.79) | LMNACCR1CCR8CYP3A4MAPT | |
| SCHEMBL11942827 | 0.75 | HSP90AA1 (0.55) | LMNACCR1CCR8CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11905287-B2 | 4-substitued cytisine analogues | THE UNIVERSITY OF BRISTOL (GB) | 2024-02-20 | — | — | US | claimed |
| US-20230203038-A1 | 4-SUBSTITUED CYTISINE ANALOGUES | THE UNIVERSITY OF BRISTOL (GB) | 2023-06-29 | — | — | US | claimed |
| US-11667638-B2 | 4-substitued cytisine analogues | THE UNIVERSITY OF BRISTOL | 2023-06-06 | — | — | US | claimed |
| EP-3500572-B1 | CYTISINE DERIVATIVES FOR THE TREATMENT OF ADDICTION | UNIV BRISTOL (GB) | 2022-10-26 | — | — | EP | claimed |
| US-20200172544-A1 | COMPOUNDS | THE UNIVERSITY OF BRISTOL (GB) | 2020-06-04 | — | — | US | claimed |
| CN-110088106-A | Compound | 布里斯托大学 | 2019-08-02 | — | — | CN | claimed |
| EP-3500572-A2 | CYTISINE DERIVATIVES FOR THE TREATMENT OF ADDICTION | The University Of Bristol (GB) | 2019-06-26 | — | — | EP | claimed |
| CN-108735393-A | A kind of environment-friendly cable production method | 临沂启阳电缆有限公司 | 2018-11-02 | — | — | CN | claimed |
| WO-2018033742-A2 | COMPOUNDS | THE UNIVERSITY OF BRISTOL (GB) | 2018-02-22 | — | — | WO | claimed |
| CN-103119713-B | The integrated antenna package that electrochemistry is powered | INTERNATIONAL BUSINESS MACHINES CORP. (US) | 2016-01-20 | — | — | CN | claimed |
| CN-103074509-A | Preparation method of brake-disc aluminum matrix compound material strengthened by silicon carbide-zirconium oxide particles | SHANDONG ZHENGNUO MACHINERY TECHNOLOGY CO LTD | 2013-05-01 | — | — | CN | claimed |
| CN-103074507-A | Carborundum-added particle-reinforced silicon aluminum alloy matrix composite for brake disc and preparation method thereof | SHANDONG ZHENGNUO MACHINERY TECHNOLOGY CO LTD | 2013-05-01 | — | — | CN | claimed |
| CN-103000723-A | Solar cell | MOTECH IND INC | 2013-03-27 | — | — | CN | claimed |
| WO-2012038843-A1 | ELECTROCHEMICALLY POWERED INTEGRATED CIRCUIT PACKAGE | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2012-03-29 | — | — | WO | claimed |
| EP-1747281-B1 | ELECTROCHEMICAL ASSAY DEVICE AND RELATED METHODS | AGAMATRIX INC (US) | 2010-09-08 | — | — | EP | claimed |
| US-20080267867-A1 | Metal Complexes of N-Heterocyclic Carbenes as Radiopharmaceuticals and Antibiotics | UNIVERSITY OF AKRON | 2008-10-30 | — | — | US | claimed |
| EP-1660444-A4 | METAL COMPLEXES OF N-HETEROCYCLIC CARBENES AS RADIOPHARMACEUTICALS AND ANTIBIOTICS | UNIV AKRON (US) | 2007-12-26 | — | — | EP | claimed |
| CN-1926141-A | Metal complexes of N-heterocyclic carbenes as radiopharmaceuticals and antibiotics | UNIV AKRON (US) | 2007-03-07 | — | — | CN | claimed |
| EP-1660444-A2 | METAL COMPLEXES OF N-HETEROCYCLIC CARBENES AS RADIOPHARMACEUTICALS AND ANTIBIOTICS | The University of Akron (US) | 2006-05-31 | — | — | EP | claimed |
| WO-2005023760-A2 | METAL COMPLEXES OF N-HETEROCYCLIC CARBENES AS RADIOPHARMACEUTICALS AND ANTIBIOTICS | THE UNIVERSITY OF AKRON (US) | 2005-03-17 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080267867-A1 | Metal Complexes of N-Heterocyclic Carbenes as Radiopharmaceuticals and Antibiotics | MKI67, C1S, CYC1 | LMNA 3541/4885CCR1 257/4885CCR8 1776/4885 |
| US-11667638-B2 | 4-substitued cytisine analogues | CES2, CDA, PCYT1A | LMNA 2856/4885CCR1 320/4885CCR8 263/4885 |
| US-20230203038-A1 | 4-SUBSTITUED CYTISINE ANALOGUES | CES2, CDA, PCYT1A | LMNA 2856/4885CCR1 320/4885CCR8 263/4885 |
| US-20200172544-A1 | COMPOUNDS | CES2, CYCS, CHKB | LMNA 1777/4885CCR1 588/4885CCR8 414/4885 |
| US-11905287-B2 | 4-substitued cytisine analogues | CES2, CDA, PCYT1A | LMNA 2856/4885CCR1 320/4885CCR8 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.