Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662312 | 0.80 | KDM4E (0.62) | SMN1; SMN2KDM4ECTBP2HDAC10HDAC6 | |
| SCHEMBL874241 | 0.79 | POLB (0.54) | ACACBSMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL2603401 | 0.78 | LTA4H (0.47) | SMN1; SMN2KDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL11249716 | 0.76 | PTGS2 (0.48) | SMN1; SMN2CTBP2ALDH1A1NPC1MAPT | |
| SCHEMBL11249712 | 0.76 | PTGS2 (0.48) | SMN1; SMN2CTBP2ALDH1A1NPC1MAPT | |
| SCHEMBL27937157 | 0.76 | FURIN (0.50) | SMN1; SMN2ALDH1A1NPC1MAPTGAA | |
| SCHEMBL3331503 | 0.76 | PLA2G4B (0.57) | ACACBSMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL11254350 | 0.75 | ALOX5 (0.57) | SMN1; SMN2CYP1A2HIF1AHDAC6ALDH1A1 | |
| SCHEMBL8339774 | 0.75 | MAPT (0.52) | KDM4EMAPTRAB9A | |
| SCHEMBL10076459 | 0.75 | ALDH1A1 (0.55) | ACACBSMN1; SMN2KDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |