Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | DHODH | Q02127 | 6/20 | 0.68 |
| ▸ | RAB9A | P51151 | 10/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6114152 | 0.98 | SMN1; SMN2 (0.72) | SMN1; SMN2DHODHRAB9AKDM4EALDH1A1 | |
| SCHEMBL4924576 | 0.88 | NPC1 (0.59) | SMN1; SMN2DHODHRAB9AKDM4EALDH1A1 | |
| SCHEMBL29101533 | 0.86 | SMN1; SMN2 (0.81) | SMN1; SMN2DHODHRAB9AKDM4EALDH1A1 | |
| SCHEMBL17324735 | 0.86 | SMN1; SMN2 (0.76) | SMN1; SMN2DHODHRAB9AKDM4EALDH1A1 | |
| SCHEMBL27971173 | 0.86 | SMN1; SMN2 (0.97) | SMN1; SMN2DHODHRAB9AKDM4EALDH1A1 | |
| SCHEMBL10235639 | 0.83 | DHODH (0.78) | SMN1; SMN2DHODHRAB9AKDM4EALDH1A1 | |
| SCHEMBL8738460 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2DHODHRAB9AKDM4EALDH1A1 | |
| SCHEMBL8738341 | 0.83 | RAB9A (0.66) | SMN1; SMN2DHODHRAB9AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6113942 | 0.82 | RAB9A (0.64) | SMN1; SMN2DHODHRAB9AKDM4EALDH1A1 | |
| Bromide SCHEMBL6121426 | 0.82 | SMN1; SMN2 (0.65) | SMN1; SMN2DHODHRAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120129842-A1 | BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-05-24 | — | — | US | disclosed |
| US-20120129842-A1 | BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129842-A1 | BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | MMP1, MMP9, MMP2 | SMN1; SMN2 4061/4885DHODH 1166/4885RAB9A 1157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.