Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29521417 | 0.98 | ACHE (0.41) | ACHEALDH1A1GAAMETAP2MMP2 | |
| SCHEMBL18306 | 0.98 | ACHE (0.41) | ACHEALDH1A1GAAMETAP2MMP2 | |
| Water SCHEMBL8505796 | 0.96 | ACHE (0.40) | ACHEALDH1A1GAAMETAP2MMP2 | |
| SCHEMBL6156461 | 0.96 | ACHE (0.40) | ACHEALDH1A1GAAMETAP2MMP2 | |
| Water SCHEMBL205546 | 0.96 | ACHE (0.40) | ACHEALDH1A1GAAMETAP2MMP2 | |
| Water SCHEMBL7386465 | 0.96 | ACHE (0.40) | ACHEALDH1A1GAAMETAP2MMP2 | |
| Hydrochloric Acid SCHEMBL3033538 | 0.96 | ACHE (0.40) | ACHEALDH1A1GAAMETAP2MMP2 | |
| Potassium SCHEMBL6156466 | 0.96 | ACHE (0.40) | ACHEALDH1A1GAAMETAP2MMP2 | |
| SCHEMBL9065359 | 0.96 | ACHE (0.40) | ACHEALDH1A1GAAMETAP2MMP2 | |
| SCHEMBL6827565 | 0.96 | ACHE (0.40) | ACHEALDH1A1GAAMETAP2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101560191-B | Alpha-menaphthyl substituted spiro bis(oxazoline) ligands, synthetic method and application thereof in synthesizing pyrazolidine derivatives | SHANGHAI INST ORGANIC CHEM | 2012-05-09 | — | — | CN | claimed |
| CN-101671313-B | Beta-naphthyl methyl substituted spiral bisoxazoline ligand, synthetic method and application thereof | SHANGHAI INST ORGANIC CHEM | 2012-05-09 | — | — | CN | claimed |
| CN-101671313-A | Beta-naphthyl methyl substituted spiral bisoxazoline ligand, synthetic method and application thereof | SHANGHAI INST ORGANIC CHEM | 2010-03-17 | — | — | CN | claimed |
| CN-101560191-A | Alpha-menaphthyl substituted spiro bis(oxazoline) ligands, synthetic method and application thereof in synthesizing pyrazolidine derivatives | SHANGHAI INST ORGANIC CHEM (CN) | 2009-10-21 | — | — | CN | claimed |
| US-7074853-B2 | Photoprotective and lightfastness-enhancing siloxanes | XEROX CORPORATION (US) | 2006-07-11 | — | — | US | claimed |
| US-20050014951-A1 | Photoprotective and lightfastness-enhancing siloxanes | XEROX CORPORATION | 2005-01-20 | — | — | US | claimed |
| US-6803395-B2 | POLYSILOXANE HAVING THEREON A HYDROPHILIC MOIETY AND A LIGHTFASTNESS MOIETY | XEROX CORPORATION | 2004-10-12 | — | — | US | claimed |
| US-20030137570-A1 | Photoprotective and lightfastness-enhancing siloxanes | XEROX CORPORATION | 2003-07-24 | — | — | US | claimed |
| US-20030133886-A1 | Photoprotective and lightfastness-enhancing siloxanes | XEROX CORPORATION | 2003-07-17 | — | — | US | claimed |
| US-6569511-B1 | Polysiloxane having a hydrophilic moiety and a lightfastness moiety; ink jet coating | XEROX CORPORATION | 2003-05-27 | — | — | US | claimed |
| US-11773064-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-03 | — | — | US | disclosed |
| US-20220363636-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2022-11-17 | — | — | US | disclosed |
| US-11420940-B2 | 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2022-08-23 | — | — | US | disclosed |
| US-20200407314-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2020-12-31 | — | — | US | disclosed |
| US-10800739-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2020-10-13 | — | — | US | disclosed |
| EP-1278719-A1 | NAPHTHAMIDE NEUROKININ ANTAGONISTS FOR USE AS MEDICAMENTS | AstraZeneca AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| WO-2002062764-A1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-08-15 | — | — | WO | disclosed |
| WO-2001098299-A1 | AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | disclosed |
| WO-2001077069-A1 | NAPHTHAMIDE NEUROKININ ANTAGONISTS FOR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2001-10-18 | — | — | WO | disclosed |
| US-5760248-A | HAVING IMPROVED METABOLIC STABILITY | A.MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014951-A1 | Photoprotective and lightfastness-enhancing siloxanes | LRRFIP1, LRRC59, MMS19 | ACHE 2950/4885ALDH1A1 656/4885GAA 4296/4885 |
| US-11773064-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | PARP1, PARP2, PARP12 | ACHE 4072/4885ALDH1A1 539/4885GAA 3795/4885 |
| US-11420940-B2 | 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors | PARP1, PARP2, PARP11 | ACHE 3980/4885ALDH1A1 235/4885GAA 2990/4885 |
| US-10800739-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | PARP1, PARP2, PARP11 | ACHE 3980/4885ALDH1A1 235/4885GAA 2990/4885 |
| US-20220363636-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | PARP1, PARP2, PARP12 | ACHE 4057/4885ALDH1A1 560/4885GAA 3793/4885 |
| US-20030133886-A1 | Photoprotective and lightfastness-enhancing siloxanes | ITGA1, ITGB1, ITGB8 | ACHE 3845/4885ALDH1A1 443/4885GAA 3850/4885 |
| US-20200407314-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | PARP1, PARP2, PARP11 | ACHE 3961/4885ALDH1A1 234/4885GAA 2967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.