Water

Water

SCHEMBL205546

O.Oc1cccc2[nH]nnc12

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.40
CHRM1 known ✓ P11229 1/20 0.36
ADRA1A known ✓ P35348 1/20 0.36
HDAC8 known ✓ Q9BY41 1/20 0.36
EGFR known ✓ P00533 1/20 0.33
MMP8 known ✓ P22894 1/20 0.33
MEN1 known ✓ O00255 1/20 0.33
PARP1 known ✓ P09874 1/20 0.33
ALDH1A1 P00352 3/20 0.36
GAA P10253 3/20 0.36
METAP2 P50579 2/20 0.36
MMP2 P08253 2/20 0.36
KMT2A Q03164 2/20 0.36
TSHR P16473 1/20 0.36
COMT P21964 1/20 0.36
METAP1 P53582 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
SOS2 Q07890 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL7386465 1.00 ACHE (0.40) ACHEALDH1A1GAAMETAP2MMP2
Water SCHEMBL8505796 1.00 ACHE (0.40) ACHEALDH1A1GAAMETAP2MMP2
Water SCHEMBL30013063 1.00 ACHE (0.40) ACHEALDH1A1GAAMETAP2MMP2
SCHEMBL18306 0.98 ACHE (0.41) ACHEALDH1A1GAAMETAP2MMP2
SCHEMBL29521417 0.98 ACHE (0.41) ACHEALDH1A1GAAMETAP2MMP2
Potassium SCHEMBL6156466 0.96 ACHE (0.40) ACHEALDH1A1GAAMETAP2MMP2
Hydrochloric Acid SCHEMBL3033538 0.96 ACHE (0.40) ACHEALDH1A1GAAMETAP2MMP2
SCHEMBL6827565 0.96 ACHE (0.40) ACHEALDH1A1GAAMETAP2MMP2
Ammonia Solution, Strong SCHEMBL873881 0.96 ACHE (0.40) ACHEALDH1A1GAAMETAP2MMP2
SCHEMBL6156461 0.96 ACHE (0.40) ACHEALDH1A1GAAMETAP2MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4287 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250340518-A1 PROCESS FOR PREPARATION OF SELUMETINIB AND SALTS THEREOF GLENMARK LIFE SCIENCES LTD (IN) 2025-11-06 US claimed
US-20250250281-A1 PROCESS FOR PREPARATION OF RELUGOLIX ALIVUS LIFE SCIENCES LIMITED (IN) 2025-08-07 US claimed
EP-4536226-A1 PROCESS FOR PREPARATION OF SELUMETINIB AND SALTS THEREOF Alivus Life Sciences Limited (IN) 2025-04-16 EP claimed
US-20240351989-A1 PROCESS FOR THE PREPARATION OF OLAPARIB, AND CRYSTALLINE FORM THEREOF ALIVUS LIFE SCIENCES LIMITED (IN) 2024-10-24 US claimed
EP-4384501-A1 PROCESS FOR THE PREPARATION OF OLAPARIB, AND CRYSTALLINE FORM THEREOF Glenmark Life Sciences Limited (IN) 2024-06-19 EP claimed
WO-2023238000-A1 PROCESS FOR PREPARATION OF SELUMETINIB AND SALTS THEREOF GLENMARK LIFE SCIENCES LIMITED (IN) 2023-12-14 WO claimed
CN-110637007-B9 Synthesis of tyrosine-derived diphenol monomers 美敦力公司 2023-08-15 CN claimed
CN-110637007-B Synthesis of tyrosine-derived diphenol monomers 美敦力公司 2023-06-16 CN claimed
WO-2023017393-A1 PROCESS FOR THE PREPARATION OF OLAPARIB, AND CRYSTALLINE FORM THEREOF GLENMARK LIFE SCIENCES LIMITED (IN) 2023-02-16 WO claimed
EP-3634944-B1 SYNTHESIS OF TYROSINE DERIVED DIPHENOL MONOMERS MEDTRONIC INC (US) 2022-06-29 EP claimed
EP-0808181-A1 PROCESS FOR THE COATING OF OBJECTS WITH HYALURONIC ACID, DERIVATIVES THEREOF, AND SEMISYNTHETIC POLYMERS FIDIA ADVANCED BIOPOLYMERS S.R.L. (IT) 1997-11-26 EP claimed
EP-0775116-A1 CARBAMAZEPINE HYDRAZIDES USEFUL IN IMMUNOASSAYS Dade Chemistry Systems Inc. (US) 1997-05-28 EP claimed
WO-1996040642-A1 CARBAMAZEPINE HYDRAZIDES USEFUL IN IMMUNOASSAYS DADE CHEMISTRY SYSTEMS INC. (US) 1996-12-19 WO claimed
WO-1996024392-A1 PROCESS FOR THE COATING OF OBJECTS WITH HYALURONIC ACID, DERIVATIVES THEREOF, AND SEMISYNTHETIC POLYMERS FIDIA ADVANCED BIOPOLYMERS, S.R.L. (IT) 1996-08-15 WO claimed
EP-0587715-A4 WATER INSOLUBLE DERIVATIVES OF POLYANIONIC POLYSACCHARIDES. GENZYME CORP (US) 1995-08-09 EP claimed
WO-1994020483-A1 PROCESS TO DERIVATIVES OF PIPERIZINYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS MERCK & CO., INC. (US) 1994-09-15 WO claimed
EP-0614894-A1 Process for the synthesis of substituted amide derivatives of piperazinylcamphorsulfonyl oxytocin antagonists MERCK & CO. INC. (US) 1994-09-14 EP claimed
EP-0587715-A1 WATER INSOLUBLE DERIVATIVES OF POLYANIONIC POLYSACCHARIDES GENZYME CORPORATION (US) 1994-03-23 EP claimed
WO-1992020349-A1 WATER INSOLUBLE DERIVATIVES OF POLYANIONIC POLYSACCHARIDES GENZYME CORPORATION (US) 1992-11-26 WO claimed
EP-0295833-A1 Aromatic-Spiropiperidine oxazepinones (and thiones) A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) 1988-12-21 EP claimed