Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.59 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.53 |
| ▸ | MITF | O75030 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CCR6 | P51684 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4A | O75164 | 1/20 | 0.48 |
| ▸ | KDM4B | O94953 | 1/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | MDM4 | O15151 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6118313 | 0.91 | ADORA3 (0.58) | ADORA3CSNK2A1MITFL3MBTL1CSNK2A2 | |
| SCHEMBL8740207 | 0.85 | CSNK2A1 (0.49) | CSNK2A1SMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL8279318 | 0.80 | EGFR (0.47) | CSNK2A1MAPT | |
| SCHEMBL8279323 | 0.80 | MEN1 (0.44) | CSNK2A1MITFSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL8738405 | 0.77 | MAPT (0.58) | SMN1; SMN2KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL8528620 | 0.76 | CSNK2A1 (0.48) | CSNK2A1SMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL6118024 | 0.76 | NPC1 (0.61) | CSNK2A1SMN1; SMN2MEN1ALDH1A1KMT2A | |
| Bromide SCHEMBL6118828 | 0.75 | CSNK2A1 (0.48) | CSNK2A1SMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL8521768 | 0.75 | MEN1 (0.57) | CSNK2A1SMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL8521250 | 0.74 | CSNK2A1 (0.47) | ADORA3CSNK2A1L3MBTL1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120129843-A1 | PYRIDYL-THIAZOLYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129843-A1 | PYRIDYL-THIAZOLYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | MMP1, MMP9, TIMP3 | ADORA3 1491/4885CSNK2A1 2619/4885MITF 2650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.