Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8031428 | 0.72 | ALDH1A1 (0.54) | GFERHTTALDH1A1MAPT | |
| SCHEMBL9590947 | 0.71 | CTNNB1 (0.45) | GAAHTTALDH1A1 | |
| SCHEMBL9136737 | 0.70 | TAS2R14 (0.48) | GAALMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL1401811 | 0.69 | CTNNB1 (0.58) | GAALMNAMEN1KMT2AHTT | |
| SCHEMBL6541960 | 0.69 | NR1H2 (0.47) | NR1H2NR1H3MMP9MMP2MMP13 | |
| SCHEMBL714086 | 0.68 | MMP2 (0.48) | MMP9MMP2MMP13ALDH1A1MCL1 | |
| SCHEMBL28378307 | 0.68 | CTNNB1 (0.56) | GAALMNAMEN1KMT2AHTT | |
| SCHEMBL27893515 | 0.68 | ALB (0.52) | LMNANPSR1ALDH1A1 | |
| SCHEMBL1466936 | 0.66 | HSD17B10 (0.48) | MMP9MMP2MMP13LMNANPSR1 | |
| SCHEMBL7567264 | 0.66 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799198-A4 | — | — | 1997-10-15 | — | — | EP | disclosed |
| EP-0799198-A1 | ANTI-INFLAMMATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-08 | — | — | EP | disclosed |
| WO-1995033461-A1 | ANTI-INFLAMMATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-14 | — | — | WO | disclosed |