Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 8/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9452733 | 0.91 | BRS3 (0.56) | BRS3AGTR1AGTR2 | |
| SCHEMBL9509637 | 0.84 | BRS3 (0.47) | BRS3FOLH1DHODHAGTR1AGTR2 | |
| SCHEMBL9529409 | 0.81 | BRS3 (0.55) | BRS3AGTR1AGTR2 | |
| SCHEMBL9304542 | 0.78 | BRS3 (0.56) | BRS3AGTR1AGTR2 | |
| SCHEMBL9510826 | 0.74 | BRS3 (0.55) | BRS3AGTR1AGTR2 | |
| SCHEMBL3737185 | 0.73 | FOLH1 (0.63) | BRS3FOLH1DHODHAGTR1AGTR2 | |
| SCHEMBL9452730 | 0.72 | BRS3 (0.57) | BRS3AGTR1AGTR2 | |
| SCHEMBL9202144 | 0.71 | AGTR1 (0.46) | BRS3FOLH1DHODHAGTR1AGTR2 | |
| SCHEMBL8741172 | 0.70 | FOLH1 (0.49) | BRS3FOLH1 | |
| SCHEMBL9200596 | 0.69 | BRS3 (0.42) | BRS3FOLH1DHODHAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724387-A4 | TREATMENT OF CHRONIC ANTI-INFLAMMATORY DISEASES BY ANGIOTENSION II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1997-06-18 | — | — | EP | disclosed |
| EP-0724387-A1 | TREATMENT OF CHRONIC ANTI-INFLAMMATORY DISEASES BY ANGIOTENSION II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995006410-A1 | TREATMENT OF CHRONIC INFLAMMATORY DISEASES BY ANGIOTENSION II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-03-09 | — | — | WO | disclosed |
| EP-0561878-A1 | USE OF ANGIOTENSIN II ANTAGONIST IN THE TREATMENT OF INFARCTION | SMITHKLINE BEECHAM PLC (GB) | 1993-09-29 | — | — | EP | disclosed |