Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.53 |
| ▸ | APLNR | P35414 | 1/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.50 |
| ▸ | NTSR1 | P30989 | 4/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.50 |
| ▸ | NTSR2 | O95665 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 4/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30901126 | 0.94 | AGTR1 (0.54) | C5AR1AGTR1APLNREPHA2NTSR1 | |
| SCHEMBL30901127 | 0.94 | C5AR1 (0.52) | C5AR1AGTR1APLNREPHA2NTSR1 | |
| SCHEMBL29602954 | 0.93 | C5AR1 (0.55) | C5AR1AGTR1NTSR1AGTR2NTSR2 | |
| SCHEMBL11162238 | 0.93 | C5AR1 (0.53) | C5AR1AGTR1APLNREPHA2NTSR1 | |
| SCHEMBL11021263 | 0.93 | C5AR1 (0.53) | C5AR1AGTR1APLNREPHA2NTSR1 | |
| Talfirastide SCHEMBL15926158 | 0.92 | AGTR1 (0.59) | C5AR1AGTR1APLNREPHA2NTSR1 | |
| SCHEMBL10924118 | 0.91 | AGTR1 (0.53) | C5AR1AGTR1APLNREPHA2NTSR1 | |
| SCHEMBL11024256 | 0.91 | C5AR1 (0.52) | C5AR1AGTR1APLNREPHA2NTSR1 | |
| SCHEMBL11208567 | 0.91 | C5AR1 (0.56) | C5AR1AGTR1APLNREPHA2AGTR2 | |
| SCHEMBL11022870 | 0.90 | AGTR1 (0.53) | C5AR1AGTR1APLNREPHA2NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724387-A4 | TREATMENT OF CHRONIC ANTI-INFLAMMATORY DISEASES BY ANGIOTENSION II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1997-06-18 | — | — | EP | disclosed |
| EP-0724387-A1 | TREATMENT OF CHRONIC ANTI-INFLAMMATORY DISEASES BY ANGIOTENSION II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995006410-A1 | TREATMENT OF CHRONIC INFLAMMATORY DISEASES BY ANGIOTENSION II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-03-09 | — | — | WO | disclosed |