SCHEMBL874183

SCHEMBL874183

NCCCCc1ccc(OCCN2CCOCC2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.61
CA12 O43570 1/20 0.56
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
CA7 P43166 1/20 0.56
CA9 Q16790 1/20 0.56
HRH3 Q9Y5N1 5/20 0.56
MAPK1 P28482 2/20 0.56
ALDH1A1 P00352 2/20 0.56
CYP1A2 P05177 1/20 0.56
CHRM2 P08172 1/20 0.56
CHRM1 P11229 1/20 0.56
HTR2A P28223 1/20 0.56
SCN1A P35498 1/20 0.56
HTR2B P41595 1/20 0.56
KCNH2 Q12809 1/20 0.56
SCN2A Q99250 1/20 0.56
SIGMAR1 Q99720 1/20 0.56
SCN3A Q9NY46 1/20 0.56
NPC1 O15118 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23963216 0.90 LTA4H (0.66) LTA4HCA12CA1CA2CA7
SCHEMBL4026244 0.89 CA12 (0.62) LTA4HCA12CA1CA2CA7
SCHEMBL874130 0.87 HRH3 (0.68) LTA4HHRH3
SCHEMBL23963137 0.86 HRH3 (0.67) LTA4HHRH3MAPK1ALDH1A1CYP1A2
SCHEMBL873542 0.85 ALDH1A1 (0.74) LTA4HHRH3MAPK1ALDH1A1CYP1A2
SCHEMBL113404 0.84 LTA4H (0.69) LTA4HCA12CA1CA2CA7
SCHEMBL23963219 0.83 TSHR (0.69) LTA4HCA12CA1CA2CA7
SCHEMBL15392094 0.82 LTA4H (0.66) LTA4HCA12CA1CA2CA7
SCHEMBL10898384 0.82 ALDH1A1 (0.68) LTA4HCA12CA1CA2CA7
Hydrochloric Acid SCHEMBL23291272 0.82 TSHR (0.67) LTA4HCA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2619184-A2 DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME The Regents of the University of Michigan (US) 2013-07-31 EP disclosed
WO-2012040527-A2 DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2012-03-29 WO disclosed