Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.68 |
| ▸ | LTA4H | P09960 | 9/20 | 0.67 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.63 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.63 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15876475 | 0.89 | LTA4H (0.72) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL23291141 | 0.88 | PSMB1 (0.71) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL15876462 | 0.88 | PSMB1 (0.71) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL874183 | 0.87 | LTA4H (0.61) | HRH3LTA4H | |
| SCHEMBL23291204 | 0.86 | LTA4H (0.68) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL4392386 | 0.85 | HRH3 (0.79) | HRH3LTA4HACHERAD52 | |
| SCHEMBL23291161 | 0.84 | HRH3 (0.82) | HRH3ACHERAD52 | |
| SCHEMBL876980 | 0.84 | LTA4H (0.75) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL6947417 | 0.83 | PSMB1 (0.73) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL23291305 | 0.83 | LTA4H (0.62) | HRH3LTA4HPSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |