Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.74 |
| ▸ | HTR2A | P28223 | 1/20 | 0.74 |
| ▸ | SCN1A | P35498 | 1/20 | 0.74 |
| ▸ | HTR2B | P41595 | 1/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.74 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.74 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | USP2 | O75604 | 2/20 | 0.72 |
| ▸ | LTA4H | P09960 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | THRB | P10828 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10898384 | 0.92 | ALDH1A1 (0.68) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL29508217 | 0.91 | ALDH1A1 (0.88) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL876980 | 0.87 | LTA4H (0.75) | HRH3LTA4HTSHR | |
| SCHEMBL4485540 | 0.85 | LTA4H (0.69) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| Pramoxine SCHEMBL26020 | 0.85 | ALDH1A1 (1.00) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL874183 | 0.85 | LTA4H (0.61) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| Pramoxine SCHEMBL180542 | 0.84 | LMNA (1.00) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL28105315 | 0.84 | SIGMAR1 (0.60) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL23963216 | 0.83 | LTA4H (0.66) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL15392094 | 0.83 | LTA4H (0.66) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |