Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10938020 | 0.85 | POLB (0.75) | POLBAPEX1MMP12MMP13MMP2 | |
| SCHEMBL10605750 | 0.80 | POLB (0.52) | POLBAPEX1MMP12MMP13MMP2 | |
| SCHEMBL830748 | 0.78 | POLB (1.00) | POLBAPEX1MMP12MMP13MMP2 | |
| SCHEMBL11223227 | 0.78 | POLB (0.63) | POLBAPEX1MMP12MMP13MMP2 | |
| SCHEMBL6233385 | 0.78 | POLB (0.63) | POLBAPEX1MMP12MMP13MMP2 | |
| SCHEMBL6236955 | 0.78 | POLB (0.63) | POLBAPEX1MMP12MMP13MMP2 | |
| SCHEMBL9271184 | 0.78 | APEX1 (0.74) | POLBAPEX1MMP12MMP13 | |
| SCHEMBL10482183 | 0.76 | POLB (0.33) | POLBAPEX1 | |
| SCHEMBL9484005 | 0.76 | POLB (0.60) | POLBAPEX1MMP12MMP13MMP2 | |
| SCHEMBL11696751 | 0.76 | APEX1 (0.79) | POLBAPEX1CAMK2AGPR84FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2618845-A1 | TUNABLE, BIODEGRADABLE LINKER MOLECULES FOR TRANSIENT CONJUGATION OF COMPONENTS IN DRUG DELIVERY SYSTEMS, AND DRUG DELIVERY SYSTEMS PREPARED THEREWITH | Cristal Delivery B.V. (NL) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012039602-A1 | TUNABLE, BIODEGRADABLE LINKER MOLECULES FOR TRANSIENT CONJUGATION OF COMPONENTS IN DRUG DELIVERY SYSTEMS, AND DRUG DELIVERY SYSTEMS PREPARED THEREWITH | UNIVERSITEIT UTRECHT HOLDING B.V. (NL) | 2012-03-29 | — | — | WO | disclosed |
| US-8034900-B2 | Water-soluble thioester and selenoester compounds and methods for making and using the same | AMYLIN PHARMACEUTICALS, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| EP-1631597-A4 | DISPLACEABLE LINKER SOLID PHASE CHEMICAL LIGATION | GRYPHON THERAPEUTICS INC (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1616003-A4 | WATER-SOLUBLE THIOESTER AND SELENOESTER COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | GRYPHON THERAPEUTICS INC (US) | 2007-06-20 | — | — | EP | disclosed |
| US-20060275768-A1 | Multiplex polymer ligation | AMYLIN PHARMACEUTICALS, INC. | 2006-12-07 | — | — | US | disclosed |
| EP-1616021-A4 | MULTIPLEX POLYMER LIGATION | GRYPHON THERAPEUTICS INC (US) | 2006-08-30 | — | — | EP | disclosed |
| US-20060173159-A1 | Water-soluble thioester and selenoester compounds and methods for making and using the same | ASTRAZENECA PHARMACEUTICALS LP | 2006-08-03 | — | — | US | disclosed |
| EP-1631597-A2 | DISPLACEABLE LINKER SOLID PHASE CHEMICAL LIGATION | Gryphon Therapeutics, Inc. (US) | 2006-03-08 | — | — | EP | disclosed |
| EP-1616003-A1 | WATER-SOLUBLE THIOESTER AND SELENOESTER COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | Gryphon Therapeutics, Inc. (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004105685-A2 | DISPLACEABLE LINKER SOLID PHASE CHEMICAL LIGATION | GRYPHON THERAPEUTICS, INC. (US) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004061094-A1 | WATER-SOLUBLE THIOESTER AND SELENOESTER COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | GRYPHON THERAPEUTICS, INC. (US) | 2004-07-22 | — | — | WO | disclosed |
| WO-2004060863-A2 | BACKBONE ANCHORED THIOESTER AND SELENOESTER GENERATORS | GRYPHON THERAPEUTICS, INC. (US) | 2004-07-22 | — | — | WO | disclosed |
| WO-2004060925-A2 | MULTIPLEX POLYMER LIGATION | GRYPHON THERAPEUTICS, INC. (US) | 2004-07-22 | — | — | WO | disclosed |
| US-20040132966-A1 | Backbone anchored thioester and selenoester generators | GRYPHON THERAPEUTICS, INC. | 2004-07-08 | — | — | US | disclosed |
| US-20040063902-A1 | Side chain anchored thioester and selenoester generators | GRYPHON THERAPEUTICS, INC. | 2004-04-01 | — | — | US | disclosed |
| WO-2004011424-A2 | SIDE CHAIN ANCHORED THIOESTER AND SELENOESTER GENERATORS | GRYPHON THERAPEUTICS, INC. (US) | 2004-02-05 | — | — | WO | disclosed |
| US-6566494-B1 | Solid support for use in the generation of preferential peptides | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2003-05-20 | — | — | US | disclosed |
| US-5917015-A | Support material for solid phase organic synthesis | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1999-06-29 | — | — | US | disclosed |
| US-4137082-A | GELATING | FUJI PHOTO FILM CO., LTD. (JP) | 1979-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132966-A1 | Backbone anchored thioester and selenoester generators | SCLY, SELENOI, ETF1 | POLB 3742/4885APEX1 985/4885MMP12 3059/4885 |
| US-20060173159-A1 | Water-soluble thioester and selenoester compounds and methods for making and using the same | SCLY, TST, SELENOI | POLB 1968/4885APEX1 682/4885MMP12 2669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.