Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | PLAT | P00750 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8742207 | 0.92 | KMT2A (0.45) | PPARGPPARACCNCCDK8MEN1 | |
| SCHEMBL2845133 | 0.90 | MEN1 (0.50) | PPARGPPARAMEN1KMT2ATDP1 | |
| SCHEMBL8742178 | 0.89 | MEN1 (0.48) | PPARGPPARACCNCCDK8MEN1 | |
| SCHEMBL9366389 | 0.82 | PPARG (0.53) | PPARGPPARAMEN1KMT2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL8742253 | 0.81 | PPARG (0.53) | PPARGPPARAMEN1KMT2ASIGMAR1 | |
| SCHEMBL10939339 | 0.81 | MEN1 (0.50) | PPARGPPARAMEN1KMT2ATDP1 | |
| SCHEMBL8742251 | 0.81 | POLB (0.50) | PPARGPPARASYKPLAUPLAT | |
| SCHEMBL10935421 | 0.77 | MEN1 (0.49) | MEN1KMT2ASYKCYP1A2CYP3A4 | |
| SCHEMBL187309 | 0.77 | MEN1 (0.50) | PPARGPPARAMEN1KMT2ATDP1 | |
| Hydrochloric Acid SCHEMBL10734951 | 0.76 | MEN1 (0.53) | PPARGPPARAMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618822-A | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1997-04-08 | — | — | US | disclosed |
| US-5599941-A | N-substituted trifluoromethylphenyltetrahydropyridines process for the preparation thereof intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1997-02-04 | — | — | US | disclosed |
| US-5596101-A | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1997-01-21 | — | — | US | disclosed |
| US-5559238-A | N-substituted trifluoromethylphenyltetrahydropyridenes process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1996-09-24 | — | — | US | disclosed |
| US-5462945-A | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1995-10-31 | — | — | US | disclosed |
| EP-0458697-B1 | N-substituted trifluoromethylphenyl tetrahydropyridines, process for their preparation, intermediates and pharmaceutical preparations containing them | SANOFI ELF (FR) | 1994-07-27 | — | — | EP | disclosed |
| US-5281606-A | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1994-01-25 | — | — | US | disclosed |
| EP-0458697-A1 | N-substituted trifluoromethylphenyl tetrahydropyridines, process for their preparation, intermediates and pharmaceutical preparations containing them | ELF SANOFI (FR) | 1991-11-27 | — | — | EP | disclosed |