Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | QDPR | P09417 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8742167 | 0.92 | PPARG (0.47) | KMT2AMEN1PPARGPPARANPSR1 | |
| SCHEMBL8742178 | 0.90 | MEN1 (0.48) | KMT2AMEN1PPARGPPARANPSR1 | |
| SCHEMBL2845133 | 0.89 | MEN1 (0.50) | KMT2AMEN1PPARGPPARANPSR1 | |
| SCHEMBL4588155 | 0.83 | PPARG (0.51) | KMT2AMEN1PPARGPPARAMAPT | |
| Hydrochloric Acid SCHEMBL8742634 | 0.82 | PPARG (0.50) | KMT2AMEN1PPARGPPARAMAPT | |
| SCHEMBL10939339 | 0.81 | MEN1 (0.50) | KMT2AMEN1PPARGPPARAMAPT | |
| SCHEMBL10935421 | 0.77 | MEN1 (0.49) | KMT2AMEN1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL187309 | 0.76 | MEN1 (0.50) | KMT2AMEN1PPARGPPARANPSR1 | |
| Hydrochloric Acid SCHEMBL10734951 | 0.76 | MEN1 (0.53) | KMT2AMEN1PPARGPPARATDP1 | |
| SCHEMBL2845134 | 0.76 | KDM4E (0.47) | KMT2AMEN1CYP2C9HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618822-A | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1997-04-08 | — | — | US | disclosed |
| US-5599941-A | N-substituted trifluoromethylphenyltetrahydropyridines process for the preparation thereof intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1997-02-04 | — | — | US | disclosed |
| US-5596101-A | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1997-01-21 | — | — | US | disclosed |
| US-5559238-A | N-substituted trifluoromethylphenyltetrahydropyridenes process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1996-09-24 | — | — | US | disclosed |
| US-5462945-A | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1995-10-31 | — | — | US | disclosed |
| EP-0458697-B1 | N-substituted trifluoromethylphenyl tetrahydropyridines, process for their preparation, intermediates and pharmaceutical preparations containing them | SANOFI ELF (FR) | 1994-07-27 | — | — | EP | disclosed |
| US-5281606-A | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1994-01-25 | — | — | US | disclosed |
| EP-0458697-A1 | N-substituted trifluoromethylphenyl tetrahydropyridines, process for their preparation, intermediates and pharmaceutical preparations containing them | ELF SANOFI (FR) | 1991-11-27 | — | — | EP | disclosed |