Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8742178 | 0.91 | MEN1 (0.48) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10939339 | 0.91 | MEN1 (0.50) | MEN1KMT2APPARGPPARACCR2 | |
| SCHEMBL8742167 | 0.90 | PPARG (0.47) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8742207 | 0.89 | KMT2A (0.45) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2845134 | 0.84 | KDM4E (0.47) | MEN1KMT2ACYP2C9CCR2KDM4E | |
| SCHEMBL10935421 | 0.81 | MEN1 (0.49) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9423057 | 0.81 | CCR2 (0.46) | MEN1KMT2APPARGPPARACCR2 | |
| SCHEMBL187309 | 0.81 | MEN1 (0.50) | MEN1KMT2ANPSR1PPARGPPARA | |
| Xaliproden SCHEMBL137094 | 0.81 | SIGMAR1 (0.51) | MEN1KMT2APPARGPPARAKDM4E | |
| Xaliproden SCHEMBL29377982 | 0.81 | SIGMAR1 (0.51) | MEN1KMT2APPARGPPARAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100021541-A1 | Microparticulate form of a Tetrahydropyridine derivative | SANOFI-AVENTIS (FR) | 2010-01-28 | — | — | US | disclosed |
| US-20080255365-A1 | Microparticulate form of a Tetrahydropyridine derivative | SANOFI-AVENTIS (FR) | 2008-10-16 | — | — | US | disclosed |
| EP-0950051-B1 | MICRO-PARTICULATE FORM OF A TETRAHYDROPYRIDIN DERIVATIVE | SANOFI SYNTHELABO (FR) | 2003-09-17 | — | — | EP | disclosed |
| US-20020192292-A1 | Microparticulate form of a tetrahydropyridin derivative | SANOFI-AVENTIS (FR) | 2002-12-19 | — | — | US | disclosed |
| US-20020028247-A1 | MICRO-PARTICULATE FORM OF A TETRAHYDROPYRIDIN DERIVATIVE | SANOFI-SYNTHEALBO (FR) | 2002-03-07 | — | — | US | disclosed |
| EP-0950051-A1 | MICRO-PARTICULATE FORM OF A TETRAHYDROPYRIDIN DERIVATIVE | SANOFI-SYNTHELABO (FR) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998028272-A1 | MICRO-PARTICULATE FORM OF A TETRAHYDROPYRIDIN DERIVATIVE | SANOFI (FR) | 1998-07-02 | — | — | WO | disclosed |
| EP-0101381-B1 | ANOREXIC TRIFLUOROMETHYL PHENYL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-12-04 | — | — | EP | disclosed |
| US-4521428-A | Anorexigenic trifluoromethylphenyltetrahydropyridines and pharmaceutical compositions containing them | SANOFI (FR) | 1985-06-04 | — | — | US | disclosed |
| EP-0101381-A1 | Anorexic trifluoromethyl phenyl tetrahydropyridines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1984-02-22 | — | — | EP | disclosed |