Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13245881 | 1.00 | LMNA (0.38) | LMNAPTGS1ALDH1A1CES2CES1 | |
| SCHEMBL8742237 | 1.00 | LMNA (0.38) | LMNAPTGS1ALDH1A1CES2CES1 | |
| SCHEMBL13811104 | 0.82 | ALDH1A1 (0.39) | LMNAALDH1A1CES2CES1HPGD | |
| SCHEMBL4442135 | 0.79 | TSHR (0.35) | LMNAALDH1A1CES2CES1TSHR | |
| SCHEMBL817341 | 0.79 | TSHR (0.35) | LMNAALDH1A1CES2CES1TSHR | |
| SCHEMBL5595601 | 0.79 | TSHR (0.35) | LMNAALDH1A1CES2CES1TSHR | |
| SCHEMBL31478174 | 0.79 | CYP1B1 (0.41) | LMNAPTGS1ALDH1A1CES2CES1 | |
| SCHEMBL5595475 | 0.78 | PRSS1 (0.47) | LMNAALDH1A1CES2CES1HPGD | |
| SCHEMBL5595477 | 0.78 | PRSS1 (0.47) | LMNAALDH1A1CES2CES1HPGD | |
| SCHEMBL23152626 | 0.77 | SMN1; SMN2 (0.42) | LMNAALDH1A1HPGDMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624941-A | Pyrazole derivatives, method of preparing them and pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-04-29 | — | — | US | disclosed |