Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PPM1D | O15297 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9716 | 0.86 | BACE1 (0.37) | ALDH1A1KMT2ACPB2CTSDBACE1 | |
| SCHEMBL9169 | 0.85 | BACE1 (0.45) | MAPTBACE1TP53VCP | |
| SCHEMBL11263 | 0.85 | HIF1A (0.36) | ALDH1A1KMT2ACPB2MAPTNPC1 | |
| SCHEMBL14321942 | 0.80 | BACE1 (0.49) | ALDH1A1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL13960 | 0.78 | MAPT (0.43) | KMT2AMAPTNPC1RAB9ATDP1 | |
| SCHEMBL14322549 | 0.75 | ALDH1A1 (0.46) | ALDH1A1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL14322551 | 0.75 | ALDH1A1 (0.46) | ALDH1A1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL9381 | 0.70 | KMT2A (0.48) | ALDH1A1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9314 | 0.70 | MEN1 (0.48) | KMT2AMAPTNPC1RAB9ATDP1 | |
| SCHEMBL2278793 | 0.69 | MEN1 (0.50) | KMT2AMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504315-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |