Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | CTSD | P07339 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.34 |
| ▸ | TPH1 | P17752 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8743 | 0.86 | ALDH1A1 (0.38) | BACE1VCPCTSDALDH1A1TDP1 | |
| SCHEMBL9169 | 0.84 | BACE1 (0.45) | BACE1VCPTP53 | |
| SCHEMBL14321923 | 0.83 | BACE1 (0.49) | BACE1CACNA1BALDH1A1OXTRAVPR1A | |
| SCHEMBL11263 | 0.79 | HIF1A (0.36) | BACE1VCPALDH1A1TDP1CPB2 | |
| SCHEMBL14321942 | 0.67 | BACE1 (0.49) | BACE1ALDH1A1TDP1KMT2ATP53 | |
| SCHEMBL14322028 | 0.66 | BACE1 (0.60) | BACE1VCPCTSDALDH1A1KMT2A | |
| SCHEMBL13969 | 0.65 | BACE1 (0.66) | BACE1CTSDKMT2A | |
| SCHEMBL13960 | 0.64 | MAPT (0.43) | TDP1KMT2ATP53 | |
| SCHEMBL13348 | 0.63 | KMT2A (0.47) | BACE1CTSDALDH1A1TDP1KMT2A | |
| SCHEMBL14321711 | 0.62 | BACE1 (0.45) | BACE1CTSDALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504315-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |