Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | PPM1D | O15297 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8743 | 0.85 | ALDH1A1 (0.38) | NPC1RAB9ASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL17620323 | 0.83 | BACE1 (0.45) | HIF1ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9169 | 0.80 | BACE1 (0.45) | TP53MAPTBACE1CTSSCTSL | |
| SCHEMBL9716 | 0.79 | BACE1 (0.37) | ALDH1A1TDP1TP53CPB2KMT2A | |
| SCHEMBL14702065 | 0.74 | SNCA (0.45) | HIF1ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14688444 | 0.73 | PDE2A (0.45) | RAB9AALDH1A1KMT2ASNCAPDE10A | |
| SCHEMBL9498 | 0.71 | KMT2A (0.42) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL14688581 | 0.70 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14688140 | 0.68 | PDE1A (0.37) | RAB9ATP53MAPTSNCA | |
| SCHEMBL14688137 | 0.68 | PDE1A (0.37) | RAB9ATP53MAPTSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504315-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |