Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.45 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8743 | 0.85 | ALDH1A1 (0.38) | BACE1VCPMAPTTP53 | |
| SCHEMBL9716 | 0.84 | BACE1 (0.37) | BACE1VCPTP53 | |
| SCHEMBL14322028 | 0.83 | BACE1 (0.60) | BACE1VCPLMNA | |
| SCHEMBL11263 | 0.80 | HIF1A (0.36) | BACE1VCPCTSLCTSSCTSK | |
| SCHEMBL28296355 | 0.68 | CLK4 (0.48) | BACE1LMNAMAPT | |
| SCHEMBL14321942 | 0.66 | BACE1 (0.49) | BACE1LMNAMAPTTP53 | |
| SCHEMBL14321923 | 0.66 | BACE1 (0.49) | BACE1LMNA | |
| SCHEMBL9686 | 0.65 | BACE1 (0.55) | BACE1LMNA | |
| SCHEMBL13960 | 0.63 | MAPT (0.43) | MAPTTP53 | |
| SCHEMBL23756529 | 0.62 | VNN1 (0.47) | CNR1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504315-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |