Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875385 | 0.86 | MAPT (0.40) | MAPTROCK1POLBLMNATDP1 | |
| SCHEMBL874210 | 0.77 | MAPT (0.40) | MAPTROCK1NPSR1TP53RXFP1 | |
| SCHEMBL3050012 | 0.76 | NLRP3 (0.40) | MAPTTP53RXFP1MEN1RAB9A | |
| SCHEMBL874570 | 0.75 | MOK (0.43) | MAPTROCK1TP53MEN1RAB9A | |
| SCHEMBL874083 | 0.74 | KDM4E (0.38) | MAPTROCK1POLBLMNATDP1 | |
| SCHEMBL874837 | 0.74 | KMT2A (0.37) | MAPTROCK1RXFP1RAB9AKMT2A | |
| SCHEMBL3053572 | 0.73 | NAMPT (0.48) | POLBROCK2HDAC1PDPK1 | |
| SCHEMBL874246 | 0.73 | PDE4B (0.44) | MAPTPOLBLMNATDP1PPARG | |
| SCHEMBL874571 | 0.72 | MAPT (0.38) | MAPTROCK1POLBLMNANPSR1 | |
| SCHEMBL874686 | 0.71 | CYP3A4 (0.42) | NPSR1CYP3A4CYP2D6CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |