SCHEMBL8743979

SCHEMBL8743979

COC1CCC(=Nc2ccc(C)cc2)CC1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.37
HPGD P15428 2/20 0.33
ALDH1A1 P00352 3/20 0.31
MAPT P10636 2/20 0.31
LMNA P02545 2/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
HTR3E A5X5Y0 1/20 0.31
SLC22A2 O15244 1/20 0.31
SLC22A1 O15245 1/20 0.31
SLC22A3 O75751 1/20 0.31
HTR3B O95264 1/20 0.31
PLAU P00749 1/20 0.31
HTR3A P46098 1/20 0.31
HTR3D Q70Z44 1/20 0.31
HTR3C Q8WXA8 1/20 0.31
ACHE P22303 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8743968 0.84 ESR2 (0.39) ALOX5ALDH1A1MAPTL3MBTL1NPC1
SCHEMBL8743983 0.84 CA12 (0.38) HPGDALDH1A1MAPTL3MBTL1SMN1; SMN2
SCHEMBL8744026 0.84 MEN1 (0.35) ALDH1A1MAPTHTR3A
SCHEMBL8744006 0.84 DPP4 (0.39) HPGDALDH1A1L3MBTL1TDP1
SCHEMBL8744074 0.80 HTR3E (0.38) HPGDALDH1A1MAPTNPC1RAB9A
SCHEMBL8743938 0.79 MAOB (0.41) HPGDALDH1A1MAPTLMNAL3MBTL1
SCHEMBL8743918 0.79 LTA4H (0.42) NPC1
SCHEMBL8743913 0.78 HPGD (0.34) HPGDALDH1A1MAPTLMNAL3MBTL1
SCHEMBL8743966 0.75 ALDH1A1 (0.33) HPGDALDH1A1MAPTLMNAL3MBTL1
SCHEMBL16620443 0.74 ALDH1A1 (0.32) HPGDALDH1A1MAPTLMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5618980-A DEHYDROGENATING N-CYCLOHEXYLIDENEAMINO COMPOUND IN PRESENCE OF HYDROGEN TRANSFER CATALYST AND HYDROGEN ACCEPTOR AND ALKALI OR ALKALINE EARTH METAL COMPOUND COCATALYST MITSUI TOATSU CHEMICALS, INC. (JP) 1997-04-08 US disclosed
EP-0588060-B1 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS (JP) 1997-04-02 EP disclosed
EP-0753505-A2 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, Inc. (JP) 1997-01-15 EP disclosed
US-5536878-A HYDROGEN ACCEPTOR MITSUI TOATSU CHEMICALS, INC. (JP) 1996-07-16 US disclosed
US-5382690-A Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1995-01-17 US disclosed
EP-0588060-A2 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, Inc. (JP) 1994-03-23 EP disclosed