SCHEMBL8744006

SCHEMBL8744006

COC1CCC(=Nc2ccccc2)CC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.39
HPGD P15428 1/20 0.32
CHRM2 P08172 2/20 0.31
ADRA2A P08913 2/20 0.31
CHRM1 P11229 2/20 0.31
DRD1 P21728 2/20 0.31
SLC6A2 P23975 2/20 0.31
ADRA1A P35348 2/20 0.31
OPRM1 P35372 2/20 0.31
DRD3 P35462 2/20 0.31
SLC6A3 Q01959 2/20 0.31
KCNH2 Q12809 2/20 0.31
HTR1A P08908 1/20 0.31
CYP2D6 P10635 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
ALDH1A1 P00352 2/20 0.30
MAPK1 P28482 1/20 0.30
CHRM4 P08173 1/20 0.30
CHRM5 P08912 1/20 0.30
DRD2 P14416 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8743918 0.87 LTA4H (0.42) DPP4HRH3
SCHEMBL8743979 0.84 ALOX5 (0.37) HPGDALDH1A1TDP1L3MBTL1
SCHEMBL8743983 0.82 CA12 (0.38) HPGDALDH1A1MAPK1TDP1L3MBTL1
SCHEMBL8744026 0.82 MEN1 (0.35) CHRM2ADRA2ACHRM1SLC6A2DRD3
SCHEMBL8743968 0.82 ESR2 (0.39) ALDH1A1GAAL3MBTL1
SCHEMBL8744074 0.82 HTR3E (0.38) HPGDCHRM2SLC6A2SLC6A3CYP2D6
SCHEMBL8743954 0.79 ALDH1A1 (0.44) ALDH1A1MAPK1GAA
SCHEMBL8743997 0.77 USP2 (0.36) DPP4HPGDALDH1A1GAACYP2C9
SCHEMBL8744151 0.75 ALDH1A1 (0.33) ALDH1A1L3MBTL1
SCHEMBL8744057 0.75 ALDH1A1 (0.33) ALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5618980-A DEHYDROGENATING N-CYCLOHEXYLIDENEAMINO COMPOUND IN PRESENCE OF HYDROGEN TRANSFER CATALYST AND HYDROGEN ACCEPTOR AND ALKALI OR ALKALINE EARTH METAL COMPOUND COCATALYST MITSUI TOATSU CHEMICALS, INC. (JP) 1997-04-08 US disclosed
EP-0588060-B1 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS (JP) 1997-04-02 EP disclosed
EP-0753505-A2 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, Inc. (JP) 1997-01-15 EP disclosed
US-5536878-A HYDROGEN ACCEPTOR MITSUI TOATSU CHEMICALS, INC. (JP) 1996-07-16 US disclosed
US-5382690-A Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1995-01-17 US disclosed
EP-0588060-A2 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, Inc. (JP) 1994-03-23 EP disclosed