Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | CASP1 | P29466 | 4/20 | 0.50 |
| ▸ | CASP7 | P55210 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874805 | 0.81 | MAPT (0.43) | ALDH1A1HSD17B10HPGDKDM4ECASP1 | |
| SCHEMBL882713 | 0.80 | CYP3A4 (0.44) | CD274ALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL874282 | 0.79 | SMN1; SMN2 (0.47) | ALDH1A1KDM4EGAAMAPTHTT | |
| SCHEMBL874795 | 0.75 | NAMPT (0.47) | — | |
| SCHEMBL12336010 | 0.74 | CD274 (0.60) | CD274HPGDHTTLMNACYP1A2 | |
| SCHEMBL10069158 | 0.72 | CD274 (0.41) | CD274ALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL873629 | 0.71 | NAMPT (0.42) | — | |
| SCHEMBL3543817 | 0.71 | CD274 (0.92) | CD274ALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL15626281 | 0.69 | LMNA (0.55) | CD274HPGDLMNAKMT2A | |
| SCHEMBL298546 | 0.69 | MAPK1 (0.56) | ALDH1A1HSD17B10HPGDKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |