Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874685 | 0.86 | RAB9A (0.46) | MAPTTP53PPARAALDH1A1RAB9A | |
| SCHEMBL875702 | 0.81 | NAMPT (0.44) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL874409 | 0.81 | CD274 (0.55) | MAPTTP53HPGDALDH1A1CYP1A2 | |
| SCHEMBL1553829 | 0.70 | MAPT (0.56) | MAPTTP53PPARAALDH1A1NPC1 | |
| SCHEMBL874282 | 0.70 | SMN1; SMN2 (0.47) | MAPTPPARAALDH1A1RAB9ACYP2C9 | |
| SCHEMBL2072755 | 0.68 | TRPM8 (0.52) | MAPTTP53PPARAALDH1A1RAB9A | |
| SCHEMBL2075214 | 0.68 | PTPN11 (0.55) | MAPTTP53ALDH1A1RAB9ANPC1 | |
| SCHEMBL2076554 | 0.67 | TRPM8 (0.64) | MAPTHPGDALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL15655693 | 0.67 | HPGD (0.53) | MAPTPPARAHPGDALDH1A1NPC1 | |
| SCHEMBL883107 | 0.66 | TRPM8 (0.49) | MAPTPPARAHPGDALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |