Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874685 | 0.83 | RAB9A (0.46) | SMN1; SMN2RAB9ALMNAMEN1KMT2A | |
| SCHEMBL874409 | 0.79 | CD274 (0.55) | HTTLMNAKMT2AMAPTCYP3A4 | |
| SCHEMBL874100 | 0.78 | RAB9A (0.64) | SMN1; SMN2RAB9ALMNAMEN1KMT2A | |
| SCHEMBL873629 | 0.77 | NAMPT (0.42) | — | |
| SCHEMBL874795 | 0.77 | NAMPT (0.47) | — | |
| SCHEMBL873644 | 0.70 | ALDH1A1 (0.61) | SMN1; SMN2RAB9ANPC1LMNAMEN1 | |
| SCHEMBL3405006 | 0.70 | CHRM4 (0.49) | SMN1; SMN2NPC1MAPTCYP2C9ALDH1A1 | |
| SCHEMBL3406028 | 0.70 | GLA (0.50) | NPC1KMT2AMAPTCYP3A4CYP2C9 | |
| SCHEMBL874805 | 0.70 | MAPT (0.43) | SMN1; SMN2RAB9ANPC1LMNAKMT2A | |
| SCHEMBL3398904 | 0.70 | POLB (0.60) | NPC1LMNAMAPTCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |