SCHEMBL8744131

SCHEMBL8744131

CC(=O)Nc1cc(C(N)=O)ccc1-c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.50
HDAC3 O15379 1/20 0.50
HDAC2 Q92769 1/20 0.50
KDM4E B2RXH2 1/20 0.48
APOBEC3A P31941 1/20 0.48
GFER P55789 1/20 0.48
APOBEC3G Q9HC16 1/20 0.48
CHEK2 O96017 2/20 0.45
SLC9A1 P19634 1/20 0.44
DHODH Q02127 1/20 0.44
NEU3 Q9UQ49 1/20 0.43
PLAU P00749 1/20 0.43
F10 P00742 1/20 0.43
MKNK1 Q9BUB5 2/20 0.43
ADORA3 P0DMS8 2/20 0.42
ADORA1 P30542 2/20 0.42
PDCD1 Q15116 1/20 0.42
CD274 Q9NZQ7 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13478362 0.81 HDAC1 (0.56) HDAC1HDAC3HDAC2KDM4EAPOBEC3A
SCHEMBL17205965 0.80 DHODH (0.52) HDAC1HDAC3HDAC2KDM4EAPOBEC3A
SCHEMBL28197533 0.80 KDM4E (0.55) HDAC1HDAC3HDAC2KDM4EAPOBEC3A
SCHEMBL6259587 0.79 F10 (0.52) HDAC1NEU3F10MEN1KMT2A
SCHEMBL5213164 0.78 KDM4E (0.59) HDAC1HDAC3HDAC2KDM4EAPOBEC3A
SCHEMBL2026663 0.77 L3MBTL1 (0.52) CHEK2DHODHPLAUMKNK1MEN1
SCHEMBL30903715 0.77 L3MBTL1 (0.52) CHEK2DHODHPLAUMKNK1MEN1
SCHEMBL99181 0.77 ALDH1A1 (0.59) HDAC1KDM4EAPOBEC3AGFERAPOBEC3G
SCHEMBL17206259 0.76 KDM4E (0.52) HDAC1KDM4EAPOBEC3AGFERAPOBEC3G
SCHEMBL2026285 0.76 ESR2 (0.55) CHEK2DHODHMKNK1MKNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020183011-A1 HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER INSTITUT CURIE (FR) 2020-09-17 WO disclosed
EP-0752982-A1 BIPHENYL DERIVATIVES AS 5HT1D ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1997-01-15 EP disclosed
WO-1995026328-A1 BIPHENYL DERIVATIVES AS 5HT1D ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-10-05 WO disclosed