Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | VHL | P40337 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846148 | 0.91 | POLB (0.51) | POLBKMT2AMEN1CTSSCTSK | |
| SCHEMBL845777 | 0.83 | POLB (0.44) | POLBKMT2AMEN1CTSSCTSK | |
| SCHEMBL845151 | 0.79 | ALDH1A1 (0.48) | POLBKMT2AMEN1CYP2C9VHL | |
| SCHEMBL845429 | 0.77 | CTSS (0.44) | POLBKMT2AMEN1CTSSCTSK | |
| SCHEMBL13272451 | 0.76 | POLB (0.41) | POLBKMT2AMEN1CTSSCTSK | |
| SCHEMBL12489978 | 0.76 | POLB (0.47) | POLBKMT2AMEN1CTSSCTSK | |
| SCHEMBL845523 | 0.76 | POLB (0.59) | POLBKMT2AMEN1CTSKCYP3A4 | |
| SCHEMBL844848 | 0.76 | POLB (0.72) | POLBKMT2AMEN1LMNANPSR1 | |
| SCHEMBL845132 | 0.76 | POLB (0.72) | POLBKMT2AMEN1LMNANPSR1 | |
| SCHEMBL845357 | 0.76 | POLB (0.72) | POLBKMT2AMEN1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |