Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ACE | P12821 | 5/20 | 0.53 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MME | P08473 | 2/20 | 0.50 |
| ▸ | CPA1 | P15085 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744782 | 1.00 | L3MBTL1 (0.57) | L3MBTL1ACETACR1NFKB1MME | |
| SCHEMBL9594563 | 0.88 | TACR1 (0.57) | L3MBTL1TACR1CTSLCTSBCTSS | |
| SCHEMBL8744805 | 0.88 | TACR1 (0.57) | L3MBTL1TACR1CTSLCTSBCTSS | |
| SCHEMBL8744826 | 0.87 | ITGB1 (0.54) | L3MBTL1ITGB1ITGA4ITGB3 | |
| SCHEMBL8744821 | 0.87 | ITGB1 (0.54) | L3MBTL1ITGB1ITGA4ITGB3 | |
| SCHEMBL1458962 | 0.86 | TACR1 (0.56) | L3MBTL1ACETACR1MMECPA1 | |
| SCHEMBL1458913 | 0.86 | TACR1 (0.56) | L3MBTL1ACETACR1MMECPA1 | |
| SCHEMBL1459337 | 0.86 | TACR1 (0.56) | L3MBTL1ACETACR1MMECPA1 | |
| SCHEMBL8744709 | 0.83 | ACE (0.55) | ACE | |
| SCHEMBL8744713 | 0.83 | ACE (0.55) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |