SCHEMBL8744733

SCHEMBL8744733

NCC(=O)c1ccccc1Br

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.50
HPGD P15428 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
HSD17B10 Q99714 1/20 0.50
KDM4E B2RXH2 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.45
LMNA P02545 1/20 0.45
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
MAPT P10636 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
HTT P42858 2/20 0.41
ELANE P08246 1/20 0.41
POLB P06746 1/20 0.40
NLRP3 Q96P20 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27533876 0.84 ALDH1A1 (0.46) ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E
SCHEMBL30089542 0.82 ALDH1A1 (0.53) ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E
SCHEMBL28053559 0.82 ALDH1A1 (0.53) ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E
SCHEMBL15979732 0.82 ALDH1A1 (0.53) ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E
SCHEMBL166468 0.80 PTPN1 (0.57) ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E
SCHEMBL29758522 0.80 PTPN1 (0.57) ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E
SCHEMBL3703924 0.80 ALDH1A1 (0.51) ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E
SCHEMBL8740774 0.80 PTPN1 (0.57) ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E
SCHEMBL634331 0.78 KMT2A (0.53) ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E
SCHEMBL12430466 0.78 ALDH1A1 (0.50) ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12398151-B2 Sumo inhibitor compounds and uses thereof Suvalent Therapeutics, Inc. (US) 2025-08-26 US disclosed
US-20220177488-A1 SUMO INHIBITOR COMPOUNDS AND USES THEREOF CIT THERAPEUTICS LLC 2022-06-09 US disclosed
US-11254687-B2 Organic light-emitting material and manufacturing method thereof, and organic light-emitting device WUHAN CHINA STAR OPTOELECTRONICS SEMICONDUCTOR DISPLAY TECHNOLOGY CO., LTD. (CN) 2022-02-22 US disclosed
US-20210403481-A1 ORGANIC LIGHT-EMITTING MATERIAL AND MANUFACTURING METHOD THEREOF, AND ORGANIC LIGHT-EMITTING DEVICE WUHAN CHINA STAR OPTOELECTRONICS SEMICONDUCTOR DISPLAY TECHNOLOGY CO., LTD. (CN) 2021-12-30 US disclosed
CN-108947900-A The method of carbon arylation tandem reaction synthesizing heterocyclic compound of the photoinduction without metal catalytic 河南大学 2018-12-07 CN disclosed
CN-1458922-A Urea derivative and adhesive-molecule inhibitor containing same as ctive ingredient TORAY INDUSTRIES (JP) 2003-11-26 CN disclosed
EP-0653421-B1 Process for preparing 2-cyanoimidazole compounds ISHIHARA SANGYO KAISHA (JP) 1997-01-15 EP disclosed
US-5552557-A Process for preparing 2-cyanoimidazole compounds by reaction of an amino ketone compound ISHIHARA SANGYO KAISHA, LTD. (JP) 1996-09-03 US disclosed
EP-0653421-A1 Process for preparing 2-cyanoimidazole compounds ISHIHARA SANGYO KAISHA LTD. (JP) 1995-05-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11254687-B2 Organic light-emitting material and manufacturing method thereof, and organic light-emitting device CYBA, SLC43A1, ABCB1 ALDH1A1 372/4885HPGD 1594/4885SMN1; SMN2 3287/4885
US-12398151-B2 Sumo inhibitor compounds and uses thereof SUMO1, SUMO2, SUMO3 ALDH1A1 1950/4885HPGD 2822/4885SMN1; SMN2 4083/4885
US-20220177488-A1 SUMO INHIBITOR COMPOUNDS AND USES THEREOF SUMO1, SUMO2, SUMO3 ALDH1A1 1950/4885HPGD 2822/4885SMN1; SMN2 4083/4885
US-20210403481-A1 ORGANIC LIGHT-EMITTING MATERIAL AND MANUFACTURING METHOD THEREOF, AND ORGANIC LIGHT-EMITTING DEVICE CYBA, SLC43A1, ABCB1 ALDH1A1 372/4885HPGD 1594/4885SMN1; SMN2 3287/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.