Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.30 |
| ▸ | CHRNG | P07510 | 2/20 | 0.30 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594732 | 0.85 | SMN1; SMN2 (0.37) | L3MBTL1ALDH1A1CYP2C19MEN1HPGD | |
| SCHEMBL8744756 | 0.73 | POLB (0.47) | L3MBTL1ALDH1A1MAPK1KDM4EPOLB | |
| SCHEMBL8744760 | 0.73 | POLB (0.47) | L3MBTL1ALDH1A1MAPK1KDM4EPOLB | |
| SCHEMBL8089290 | 0.71 | L3MBTL1 (0.33) | L3MBTL1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL12214120 | 0.71 | KDM4E (0.42) | L3MBTL1ALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL8090802 | 0.70 | MAPT (0.36) | L3MBTL1KDM4EMEN1KMT2AHTT | |
| SCHEMBL8082684 | 0.69 | NLRP3 (0.34) | L3MBTL1ALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL7447714 | 0.68 | MEN1 (0.47) | L3MBTL1ALDH1A1CYP2C19MEN1HPGD | |
| SCHEMBL10999349 | 0.66 | TSHR (0.41) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL8744741 | 0.66 | KDM4E (0.33) | L3MBTL1ALDH1A1KDM4EHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |