Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.39 |
| ▸ | VHL | P40337 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744760 | 1.00 | POLB (0.47) | POLBALDH1A1KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL6990342 | 0.87 | SHMT2 (0.44) | POLBALDH1A1KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL6990345 | 0.87 | SHMT2 (0.44) | POLBALDH1A1KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL8744704 | 0.84 | THRA (0.45) | KDM4EPSMB5THRATHRB | |
| SCHEMBL8744706 | 0.84 | THRA (0.45) | KDM4EPSMB5THRATHRB | |
| SCHEMBL8744819 | 0.83 | MAPK1 (0.56) | POLBALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL8744827 | 0.83 | MAPK1 (0.56) | POLBALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL8744813 | 0.83 | LMNA (0.41) | SMN1; SMN2PSMB5LMNAL3MBTL1 | |
| SCHEMBL9595368 | 0.83 | LMNA (0.41) | SMN1; SMN2PSMB5LMNAL3MBTL1 | |
| SCHEMBL8744747 | 0.81 | KMT2A (0.54) | ALDH1A1L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |