Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594066 | 1.00 | KMT2A (0.42) | KMT2AGFERLMNAALDH1A1TYR | |
| SCHEMBL9595171 | 0.90 | ALDH1A1 (0.42) | KMT2AGFERLMNAALDH1A1PSMB5 | |
| SCHEMBL8744786 | 0.90 | ALDH1A1 (0.42) | KMT2AGFERLMNAALDH1A1PSMB5 | |
| SCHEMBL8744770 | 0.86 | PYGL (0.38) | KMT2AGFERLMNAALDH1A1PSMB5 | |
| SCHEMBL9596067 | 0.86 | PYGL (0.38) | KMT2AGFERLMNAALDH1A1PSMB5 | |
| SCHEMBL8744757 | 0.86 | KMT2A (0.54) | KMT2AGFERALDH1A1PYGLCYP2C9 | |
| SCHEMBL8744747 | 0.86 | KMT2A (0.54) | KMT2AGFERALDH1A1PYGLCYP2C9 | |
| SCHEMBL9595368 | 0.84 | LMNA (0.41) | LMNAPSMB5NLRP3 | |
| SCHEMBL8744813 | 0.84 | LMNA (0.41) | LMNAPSMB5NLRP3 | |
| SCHEMBL7964632 | 0.84 | ALDH1A1 (0.50) | KMT2AGFERLMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |